Megapime 2 gm/vial (IV Injection)
2 gm vial: ৳ 1,100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefepime hydrochloride |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of pneumonia caused by susceptible strains of microorganisms
- Treatment of febrile neutropenia
- Treatment of urinary tract infections
- Treatment of skin and skin structure infections
- Treatment of intra-abdominal infections
- Empiric therapy for febrile neutropenic patients
Pharmacology
- Bactericidal mode of action
- Disruption of peptidoglycan synthesis
- Importance in Gram-positive organisms
- Inhibition of penicillin binding proteins (PBPs)
Dosage & Administration
- Intravenous administration over approximately 30 minutes
- Specific dosages for different types of infections
- Duration of treatment based on infection severity
Interaction
- Potential nephrotoxicity with aminoglycosides
- Reports of nephrotoxicity with concomitant administration of cephalosporins and diuretics
Contraindications
- Immediate hypersensitivity reactions to cefepime or cephalosporin class of antibiotics
- Contradictions with penicillin or other betalactum antibiotics
Side Effects
- Immediate hypersensitivity reactions to cefepime or cephalosporin class of antibiotics
- Risk of drug-resistant bacteria development
Pregnancy & Lactation
- Pregnancy Category B
- Caution during pregnancy and breastfeeding due to low concentrations in breast milk
Precautions & Warnings
- Prescribing only in case of proven or strongly suspected bacterial infection
- Overgrowth of non-susceptible microorganisms possible with prolonged use
- Association with fall in prothrombin activity
- Caution in patients with gastrointestinal disease
- Potential alteration of glucose metabolism and serum potassium with arginine
Use in Special Populations
- Maximum pediatric dose not to exceed recommended adult dose
- Serious adverse events in geriatric patients with renal insufficiency
- No adjustment for patients with impaired hepatic function
- Dose adjustment in patients with impaired renal function
Overdose Effects
- Observation and supportive treatment for overdose
- Recommendation for hemodialysis in the presence of renal insufficiency
- Symptoms of overdose include encephalopathy, seizures, and neuromuscular excitability
Therapeutic Class
- Fourth generation Cephalosporins
Reconstitution
- Specific recommendations for reconstituting IV and IM formulations
- Compatibility with different IV infusion fluids and diluents
Storage Conditions
- Do not use beyond expiry date
- Keep out of reach of children
- Dispensing on prescription of a registered physician only