Pime-4 1 gm/vial (IM/IV Injection)

1 gm vial: ৳ 553.73

Medicine Details

Category Details
Generic Cefepime hydrochloride
Company Aci limited
Also available as
Pime 4 500 mg injection

Indications

  • Treatment of moderate to severe pneumonia
  • Treatment of febrile neutropenia
  • Treatment of uncomplicated and complicated urinary tract infections
  • Treatment of uncomplicated skin and skin structure infections
  • Treatment of complicated intra-abdominal infections

Pharmacology

  • Bactericidal nature
  • Mode of action disruption of peptidoglycan layer
  • Similar mode of action to penicillins
  • Disruption of synthesis of bacterial cell walls

Dosage & Administration

  • Intravenous administration over 30 minutes
  • Various dosages for different infections
  • Duration of treatment for different infections
  • Notes on administration routes
  • Caution for specific patient groups

Interaction

  • Monitoring renal function during aminoglycosides administration
  • Potential nephrotoxicity and ototoxicity
  • Nephrotoxicity with cephalosporins and diuretics

Contraindications

  • Immediate hypersensitivity reactions to cefepime or cephalosporins
  • Contraindicated in certain antibiotic allergies

Side Effects

  • Potential adverse reactions
  • Allergic reactions
  • Possible contraindications

Pregnancy & Lactation

  • Pregnancy Category B
  • Caution in use during pregnancy
  • Excretion in breast milk
  • Nursing woman caution

Precautions & Warnings

  • Appropriate prescribing for bacterial infection
  • Potential overgrowth of non-susceptible microorganisms
  • Monitoring patient's condition
  • Association with fall in prothrombin activity
  • Caution in individuals with gastrointestinal disease
  • Effects on glucose metabolism and serum potassium

Use in Special Populations

  • Pediatric use and dosage
  • Geriatric use and potential adverse events
  • Impaired hepatic and renal function adjustments
  • Dose adjustment for impaired renal function

Overdose Effects

  • Observation and supportive treatment for overdosed patients
  • Hemodialysis for renal insufficiency
  • Symptoms of overdose

Therapeutic Class

  • Fourth generation Cephalosporins

Reconstitution

  • Administration methods
  • Compatibility with IV fluids and diluents
  • Instructions for vial reconstitution

Storage Conditions

  • Expiry date
  • Keep out of reach of children
  • Dispensing on physician prescription

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