Ultrapime 500 mg/vial (IM/IV Injection)

500 mg vial: ৳ 300.00

Medicine Details

Category Details
Generic Cefepime hydrochloride
Company Incepta pharmaceuticals ltd
Also available as
Ultrapime 1 gm injection Ultrapime 2 gm injection

Title

  • Ultrapime 1 gm
  • Cefepime Injection

Categories

  • Medicine
  • Antibiotic
  • Intravenous Drug

Description

  • Ultrapime is indicated for the treatment of pneumonia, febrile neutropenia, urinary tract infections, skin infections, intra-abdominal infections, and more.
  • Cefepime should be administered intravenously over approximately 30 minutes.
  • Renal function should be monitored carefully if high doses of aminoglycosides are to be administered with Ultrapime.
  • Pregnancy Category B. Cefepime is excreted in human breast milk in very low concentrations. Caution should be exercised when cefepime is administered to a nursing woman.

Color Options

  • Clear solution for injection

Dimensions

  • Varying volume of reconstitution solution based on vial size

Mode of Action

  • Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The final transpeptidation step is facilitated by transpeptidases known as penicillin binding proteins (PBPs).

Dosage and Administration

  • 1-2 gm IV 12 hourly for 10 days for moderate to severe pneumonia
  • 2 gm IV 8 hourly for 7 days for empiric therapy for febrile neutropenic patients
  • 0.5-1 gm IV/IM 12 hourly for 7-10 days for mild to moderate urinary tract infections, including pyelonephritis.
  • 2 gm IV 12 hourly for 10 days for severe uncomplicated or complicated urinary tract infections, including pyelonephritis.
  • 2 gm IV 12 hourly for 10 days for moderate to severe uncomplicated skin and skin structure infections.
  • 2 gm IV 12 hourly for 7-10 days for complicated intra-abdominal infections in combination with metronidazole.

Interaction

  • Carefully monitor renal function if high doses of aminoglycosides are administered with Ultrapime.
  • Nephrotoxicity has been reported following concomitant administration of other cephalosporins with potent diuretics such as furosemide.

Contraindications

  • Hypersensitivity reactions to cefepime or the cephalosporin class of antibiotics, penicillin, or other betalactum antibiotics.

Side Effects

  • Hypersensitivity reactions to cefepime or the cephalosporin class of antibiotics, penicillin, or other betalactum antibiotics.

Pregnancy and Lactation

  • Pregnancy Category B. Cefepime is excreted in human breast milk in very low concentrations. Caution should be exercised when cefepime is administered to a nursing woman.

Precautions and Warnings

  • Prescribing Ultrapime in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient.
  • Prolonged use of Ultrapime may result in overgrowth of non-susceptible microorganisms.
  • Prothrombin time should be monitored in patients at risk.
  • Use with caution in individuals with a history of gastrointestinal disease, particularly colitis.
  • Arginine has been shown to alter glucose metabolism and elevate serum potassium transiently when administered at high doses.

Use in Special Populations

  • The maximum dose for pediatric patients should not exceed the recommended adult dose.
  • Serious adverse events have occurred in geriatric patients with renal insufficiency given unadjusted doses of cefepime.
  • No dose adjustment is necessary for patients with impaired hepatic function.
  • Dose adjustment is needed in patients with impaired renal function (creatinine clearance <60 ml/min).

Overdose Effects

  • Patients who receive an overdose should be carefully observed and given supportive treatment.
  • In the presence of renal insufficiency, hemodialysis is recommended to aid the removal of cefepime from the body.
  • Symptoms of overdose include encephalopathy, myoclonus, seizures, and neuromuscular excitability.

Therapeutic Class

  • Fourth generation Cephalosporins

Reconstitution

  • For IV, the resulting solution should be injected directly into the vein over a period of three to five minutes or injected into the tubing of an administration set while the patient is receiving a compatible IV fluid.
  • IM route of administration is indicated only for specific cases.
  • Ultrapime is compatible with various IV infusion fluids and diluents for IM administration.

Storage Conditions

  • Do not use later than the date of expiry.
  • Keep all medicines out of the reach of children.
  • To be dispensed only on the prescription of a registered physician.

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