Unipim 500 mg/vial (IM/IV Injection)

500 mg vial: ৳ 301.00

Medicine Details

Category Details
Generic Cefepime hydrochloride
Company Drug international ltd
Also available as
Unipim 1 gm injection

Title

  • Unipim 4th Generation Cephalosporin Antibiotic

Categories

  • Medicine
  • Antibiotic
  • Cephalosporin

Indications

  • Treatment of moderate to severe pneumonia caused by specific microorganisms
  • Empiric treatment for febrile neutropenic patients
  • Treatment of uncomplicated and complicated urinary tract infections
  • Treatment of uncomplicated skin and skin structure infections
  • Treatment of complicated intra-abdominal infections (in combination with metronidazole)

Pharmacology

  • Bactericidal action
  • Disruption of peptidoglycan layer synthesis in bacterial cell walls
  • Similar mode of action to other beta-lactam antibiotics

Dosage & Administration

  • Administered intravenously over approximately 30 minutes
  • Dosage varies based on the type and severity of the infection

Interaction

  • Monitoring of renal function when administered with aminoglycosides
  • Potential nephrotoxicity and ototoxicity with aminoglycoside antibiotics
  • Nephrotoxicity risk with concomitant administration of other cephalosporins and potent diuretics

Contraindications

  • Immediate hypersensitivity to cefepime or cephalosporin class of antibiotics
  • Hypersensitivity to penicillin or other betalactum antibiotics

Side Effects

  • Possible immediate hypersensitivity reactions

Pregnancy & Lactation

  • Pregnancy Category B
  • Excretion in human breast milk in very low concentrations

Precautions & Warnings

  • Avoid prescribing in the absence of a proven or strongly suspected bacterial infection
  • Potential overgrowth of non-susceptible microorganisms with prolonged use
  • Association with a fall in prothrombin activity
  • Caution in individuals with a history of gastrointestinal disease
  • Potential glucose metabolism alteration with arginine administration

Use in Special Populations

  • Pediatric use up to 16 years with maximum dose restriction
  • Geriatric use and risk of serious adverse events in renal insufficiency
  • Renal function adjustment in impaired renal function patients

Overdose Effects

  • Careful observation and supportive treatment for patients receiving overdose
  • Recommendation for hemodialysis in the presence of renal insufficiency

Therapeutic Class

  • Fourth generation Cephalosporins

Reconstitution

  • Intravenous and intramuscular administration instructions
  • Compatibility with specific IV infusion fluids and diluents
  • List of amounts of diluent to be added for different dosage vials

Storage Conditions

  • Dispensing only on prescription of a registered physician
  • Expiry date check
  • Keep out of reach of children

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