Magnova 1 gm/vial (IM/IV Injection)

1 gm vial: ৳ 551.65

Medicine Details

Category Details
Generic Cefepime hydrochloride
Company Orion pharma ltd
Also available as
Magnova 500 mg injection

Indications

  • Treatment for moderate to severe pneumonia caused by specific strains of microorganisms
  • Empiric treatment for febrile neutropenic patients
  • Treatment for urinary tract infections and skin infections
  • Treatment for complicated intra-abdominal infections

Categories

  • Antibiotic
  • Fourth generation Cephalosporins

Dosage & Administration

  • Administered intravenously over approximately 30 minutes
  • Specific dosages for different types of infections
  • Dosage adjustments for patients with renal impairment

Mode of Action

  • Bactericidal effect similar to other beta-lactam antibiotics
  • Disrupts synthesis of peptidoglycan layer of bacterial cell walls

Interaction

  • Monitor renal function if administered with high doses of aminoglycosides
  • Risk of nephrotoxicity with concomitant administration of potent diuretics

Contraindications

  • Immediate hypersensitivity reactions to cephalosporins, penicillin, or other beta-lactum antibiotics

Side Effects

  • Potential for immediate hypersensitivity reactions
  • Risk of overgrowth of non-susceptible microorganisms

Pregnancy & Lactation

  • Pregnancy Category B
  • Excreted in low concentrations in human breast milk

Precautions & Warnings

  • Avoid use in absence of bacterial infection
  • Monitor for prothrombin activity
  • Prescribe with caution in patients with gastrointestinal diseases

Use in Special Populations

  • Pediatric use with maximum dose restriction
  • Geriatric use with risk of serious adverse events
  • No adjustment necessary for impaired hepatic function
  • Dose adjustment needed for impaired renal function

Overdose Effects

  • Careful observation and supportive treatment for overdose
  • Hemodialysis recommended in renal insufficiency
  • Symptoms include encephalopathy, seizures, and neuromuscular excitability

Therapeutic Class

  • Fourth generation Cephalosporins

Reconstitution

  • Intravenous and Intramuscular administration guidelines
  • Compatibility with various IV fluids and diluents
  • Specific volumes of diluent to be added for different vial sizes

Storage Conditions

  • Do not use after expiry date
  • Keep out of reach of children
  • Dispensed only with a registered physician's prescription

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