Superpime 1 gm/vial (IM/IV Injection)
1 gm vial: ৳ 551.64
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefepime hydrochloride |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Treatment of Pneumonia (moderate to severe)
- Febrile Neutropenia treatment
- Treatment of Uncomplicated and Complicated Urinary Tract Infections
- Treatment of Uncomplicated Skin and Skin Structure Infections
- Treatment of Complicated Intra-abdominal Infections
Pharmacology
- Bactericidal mode of action
- Disruption of peptidoglycan layer synthesis
- Importance for cell wall structural integrity
- Facilitation by transpeptidases known as penicillin binding proteins
Dosage & Administration
- Intravenous administration over approximately 30 minutes
- Specific dosages for different infections
- Empiric therapy for febrile neutropenic patients
- Route of administration considerations
- Monitoring prothrombin time in at-risk patients
Interaction
- Need for careful renal function monitoring
- Potential nephrotoxicity and ototoxicity with aminoglycosides
- Reported nephrotoxicity with concomitant use of other cephalosporins and potent diuretics
Contraindications
- Immediate hypersensitivity reactions to cefepime or cephalosporin class of antibiotics
- Contraindication for patients with hypersensitivity to penicillin or other betalactum antibiotics
Side Effects
- Immediate hypersensitivity reactions
Pregnancy & Lactation
- Pregnancy Category B
- Excretion in human breast milk
- Caution in administration to a nursing woman
Precautions & Warnings
- Avoiding prescribing in absence of proven or strongly suspected bacterial infection
- Prolonged use may result in overgrowth of non susceptible microorganisms
- Association with fall in prothrombin activity
- Prescribing caution for individuals with a history of gastrointestinal disease
- Effect of Arginine on glucose metabolism and serum potassium
Use in Special Populations
- Pediatric Use up to 16 years
- Geriatric Use with renal insufficiency
- No adjustment necessary for patients with impaired hepatic function
- Dose adjustment for patients with impaired renal function
- Supportive treatment for overdose
Overdose Effects
- Careful observation and supportive treatment for patients who receive an overdose
- Recommendation for hemodialysis in the presence of renal insufficiency
- Symptoms of overdose include encephalopathy, myoclonus, seizures
Therapeutic Class
- Fourth generation cephalosporins
Reconstitution
- Specific instructions for intravenous and intramuscular administration
- Compatibility with different IV infusion fluids and diluents
Storage Conditions
- Expiry date consideration
- Dispensing only on the prescription of a registered physician