Zopime 500 mg/vial (IM/IV Injection)

500 mg vial: ৳ 300.00

Medicine Details

Category Details
Generic Cefepime hydrochloride
Company Healthcare pharmaceuticals ltd
Also available as
Zopime 1 gm injection

Title

  • Zopime

Categories

  • Medicine
  • Antibiotic
  • Fourth Generation Cephalosporin

Description

  • Cefepime is indicated for the treatment of various infections caused by susceptible strains of microorganisms.
  • It is administered intravenously over approximately 30 minutes.
  • The pharmacology involves disrupting the synthesis of the peptidoglycan layer of bacterial cell walls.
  • The dosage and administration vary based on the type and severity of infection.
  • It should be used with caution in individuals with a history of gastrointestinal disease.
  • Pregnant and nursing women should exercise caution when using cefepime.
  • Pediatric and geriatric use have specific dosage considerations.
  • In the case of overdose, supportive treatment and careful observation are required.
  • It belongs to the therapeutic class of Fourth Generation Cephalosporins.
  • The reconstitution process involves specific diluents and compatible IV infusion fluids.
  • Proper storage conditions are essential, and it should not be used after the expiry date.

Indications

  • Pneumonia (moderate to severe)
  • Febrile Neutropenia
  • Uncomplicated and Complicated Urinary Tract Infections (including pyelonephritis)
  • Uncomplicated Skin and Skin Structure Infections
  • Complicated Intra-abdominal Infections (used in combination with metronidazole)

Pharmacology

  • Disruption of the synthesis of the peptidoglycan layer of bacterial cell walls

Dosage & Administration

  • Administered intravenously over approximately 30 minutes
  • Dosage varies based on the type and severity of infection

Interaction

  • Renal function should be monitored carefully if high doses of aminoglycosides are to be administered with cefepime
  • Nephrotoxicity has been reported following concomitant administration of other cephalosporins with potent diuretics

Contraindications

  • Patients with immediate hypersensitivity reactions to cefepime or the cephalosporin class of antibiotics, penicillin, or other betalactum antibiotics

Side Effects

  • Immediate hypersensitivity reactions

Pregnancy & Lactation

  • Pregnancy Category B
  • Excretion in human breast milk in very low concentrations

Precautions & Warnings

  • Prescribing in the absence of proven or strongly suspected bacterial infection
  • Prolonged use may result in overgrowth of non susceptible microorganisms
  • Fall in prothrombin activity
  • Prescribed with caution in individuals with a history of gastrointestinal disease

Use in Special Populations

  • Pediatric Use (2 months up to 16 years)
  • Geriatric Use
  • Impaired Hepatic Function
  • Impaired Renal Function

Overdose Effects

  • Careful observation and supportive treatment
  • Hemodialysis is recommended in the presence of renal insufficiency

Therapeutic Class

  • Fourth Generation Cephalosporins

Reconstitution

  • Intravenous and intramuscular administration
  • Specific diluents and compatible IV infusion fluids

Storage Conditions

  • Do not use later than the date of expiry
  • Keep all medicines out of the reach of children
  • To be dispensed only on the prescription of a registered physician

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