Imbac (500 mg+500 mg)/vial (IV Injection)

Indications

• Lower respiratory tract infections
• Urinary tract infections
• Intra-abdominal infections
• Gynecologic infections
• Bacterial septicemia
• Bone and joint infections
• Skin and skin structure infections
• Endocarditis

Pharmacology

• Bactericidal activity
• Inhibition of cell wall synthesis
• Stability in the presence of beta-lactamases
• Potent inhibitor of beta-lactamases
• Affinity for penicillin binding proteins
• Lethal effect related to binding to specific PBPs

Dosage & Administration

• Dosage based on suspected or confirmed pathogen susceptibility
• Recommended dosage regimens for adult patients
• Dosing reduction for patients with reduced creatinine clearance
• Dosage recommendations for pediatric patients
• Reconstitution with appropriate diluent
• Intravenous infusion administration

Interaction

• Concurrent administration with probenecid
• Increased risk of seizures with concurrent ganciclovir use

Contraindications

• Hypersensitivity to any component of the combination

Side Effects

• Phlebitis
• Nausea, diarrhea, vomiting
• Rash, pruritus, urticaria
• Pain at injection site, erythema, induration
• Fever
• Hypotension
• Seizures, dizziness, somnolence

Pregnancy & Lactation

• Pregnancy Category C
• Caution in use during pregnancy
• Unknown excretion in human milk
• Caution in administration to nursing women

Precautions & Warnings

• Serious hypersensitivity reactions
• Seizure potential and CNS adverse reactions
• Immediate discontinuation in case of allergic reactions
• Neurological evaluation in case of tremors, myoclonus, or seizures

Therapeutic Class

• Other beta-lactam Antibiotics

Reconstitution

• Avoidance of benzyl alcohol-containing diluents for neonates
• Reconstitution with 0.9% Sodium Chloride Injection
• Variations in color not affecting potency
• No direct intravenous infusion of reconstituted suspension
• Visual inspection for particulate matter and discoloration
• Storage and shelf life of reconstituted solutions

Storage Conditions

• Storage temperature at or below 25° C
• Protection from light and moisture
• Keep out of reach of children

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