Iminem (500 mg+500 mg)/vial (IV Injection)

Unit Price: ৳ 1,203.12

Medicine Details

Category Details
Generic Imipenem cilastatin
Company Aci limited
Also available as
Iminem 250 mg injection

Indications

  • Lower respiratory tract infections
  • Urinary tract infections
  • Intra-abdominal infections
  • Gynecologic infections
  • Bacterial septicemia
  • Bone and joint infections
  • Skin and skin structure infections
  • Endocarditis

Pharmacology

Imipenem is a penem antibacterial drug with bactericidal activity resulting from the inhibition of cell wall synthesis. Cilastatin sodium is a renal dehydropeptidase inhibitor that limits the renal metabolism of imipenem.

Dosage & Administration

  • Adult Patients:
    • Dosage based on suspected or confirmed pathogen susceptibility
    • Recommended dosage regimens: 500 mg every 6 hours, 1000 mg every 8 hours, 1000 mg every 6 hours
    • Dose reduction for patients with creatinine clearance of less than 90 mL/min
    • Patients with creatinine clearances of less than 15 mL/min should not receive this combination unless hemodialysis is instituted within 48 hours
  • Pediatric Patients for Non-CNS Infections:
    • Greater than or equal to 3 Months of Age: 15-25 mg/kg in every 6 hours
    • Less than or equal to 3 months of age: 4 weeks to 3 months of age: 25 mg/kg in every 6 hours, 1 to 4 weeks of age: 25 mg/kg in every 8 hours, Less than 1 week of age: 25 mg/kg in every 12 hours
  • Administration Method: Reconstitute with appropriate diluent and dilute the suspension with an appropriate infusion solution before administering by intravenous infusion

Interaction

  • Concurrent admin with probenecid may increase the half-life of cilastatin
  • Increased risk of generalized seizures when used concurrently with ganciclovir

Contraindications

Hypersensitivity to any component of this combination

Side Effects

  • Phlebitis
  • Nausea, diarrhea, vomiting
  • Rash, pruritus, urticaria
  • Pain at injection site, erythema at injection site, vein induration
  • Fever
  • Hypotension
  • Seizures, dizziness, somnolence

Pregnancy & Lactation

  • Pregnancy Category: C
  • Usage in Pregnancy: Should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus
  • Usage in Lactation: Caution should be exercised when administered to a nursing woman

Precautions & Warnings

  • Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. Discontinue the drug immediately if an allergic reaction occurs
  • Seizure Potential: Seizures and other CNS adverse reactions have been reported during treatment with this combination

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Reconstitution and Preparation:
    • Do not use diluents containing benzyl alcohol to reconstitute for administration to neonates
    • Contents of the vials must be reconstituted by adding approximately 10 mL of 0.9% Sodium Chloride Injection
    • The reconstituted suspension must not be administered by direct Intravenous Infusion
    • Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration
  • Storage of Reconstituted Solutions: Satisfactory potency for 4 hours at room temperature or for 24 hours under refrigeration (5°C)

Storage Conditions

Store at or below 25°C temperature. Keep away from light and wet place. Keep out of reach of children

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