Aronem 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,350.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Aci limited
Also available as

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action by interfering with bacterial cell wall synthesis

Dosage

  • Adults:
    • 500 mg to 1 gm by intravenous administration every 8 hours
    • Up to 2 gm for cystic fibrosis
    • 2 gm for meningitis
  • Children:
    • 10 to 40 mg/kg intravenously every 8 hours
    • 20 mg/kg for intra-abdominal infections
    • 25-40 mg/kg for cystic fibrosis (4-18 years)
    • 40 mg/kg for meningitis
    • 20 mg/kg for febrile neutropenia
    • Use adult dosage for children over 50 kg weight
    • No experience in children with hepatic or renal impairment

Administration

Intravenous infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes

Interaction

Probenecid competes with Aronem for active tubular secretion, may reduce serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B, caution when administered to a nursing woman

Precautions & Warnings

Discontinue in case of allergic reaction, careful monitoring in patients with hepatic disease

Use in Special Populations

  • Dosage reduction in patients with creatinine clearance less than 51 ml/min
  • No dosage adjustments necessary in elderly patients unless creatinine clearance is <51 ml/min
  • Efficacy and tolerability in infants under 3 months not established

Overdose Effects

Accidental overdose could occur during therapy, treatment should be symptomatic

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

Intravenous bolus and infusion administration with compatible infusion fluids

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children

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