Aronem 1 gm/vial (IV Injection or Infusion)
Medicine Details
Category | Details |
---|---|
Generic | Meropenem trihydrate |
Company | Aci limited |
Also available as |
Indications
- Pneumonia and Nosocomial Pneumonia
- Urinary Tract Infections
- Intra-abdominal Infections
- Gynaecological Infections
- Skin and Skin Structure Infections
- Meningitis
- Septicaemia
- Pulmonary infections in cystic fibrosis
- Empiric treatment for presumed infections in patients with febrile neutropenia
Pharmacology
Bactericidal action by interfering with bacterial cell wall synthesis
Dosage
- Adults:
- 500 mg to 1 gm by intravenous administration every 8 hours
- Up to 2 gm for cystic fibrosis
- 2 gm for meningitis
- Children:
- 10 to 40 mg/kg intravenously every 8 hours
- 20 mg/kg for intra-abdominal infections
- 25-40 mg/kg for cystic fibrosis (4-18 years)
- 40 mg/kg for meningitis
- 20 mg/kg for febrile neutropenia
- Use adult dosage for children over 50 kg weight
- No experience in children with hepatic or renal impairment
Administration
Intravenous infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes
Interaction
Probenecid competes with Aronem for active tubular secretion, may reduce serum valproic acid levels
Contraindications
Hypersensitivity to the product
Side Effects
- Inflammation
- Thrombophlebitis
- Pain at the site of injection
- Skin reactions like rash, pruritus, urticaria
- Abdominal pain
- Nausea
- Vomiting
- Diarrhea
- Headache
Pregnancy & Lactation
Pregnancy Category B, caution when administered to a nursing woman
Precautions & Warnings
Discontinue in case of allergic reaction, careful monitoring in patients with hepatic disease
Use in Special Populations
- Dosage reduction in patients with creatinine clearance less than 51 ml/min
- No dosage adjustments necessary in elderly patients unless creatinine clearance is <51 ml/min
- Efficacy and tolerability in infants under 3 months not established
Overdose Effects
Accidental overdose could occur during therapy, treatment should be symptomatic
Therapeutic Class
Other beta-lactam Antibiotics
Reconstitution
Intravenous bolus and infusion administration with compatible infusion fluids
Storage Conditions
Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children
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