Aropen 1 gm/vial (IV Injection or Infusion)

1 mg vial: ৳ 1,200.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Aristopharma ltd
Also available as
Aropen 500 mg injection

Title

  • Aropen (Meropenem)

Categories

  • Pharmaceuticals
  • Antibiotics
  • Intravenous Medication

Description

  • Aropen is indicated for the treatment of various bacterial infections in adults and children.

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

  • Interferes with bacterial cell wall synthesis
  • Potent activity against a broad spectrum of bacteria
  • Bactericidal action
  • Effective against Gram-positive and Gram-negative bacteria
  • Carbapenem antibiotic for parenteral use

Dosage

  • Adult dosage: 500 mg to 1 gm by intravenous administration every 8 hours
  • Recommended daily dosage depending on type and severity of infection and patient's condition
  • Children dosage: 10 to 40 mg/kg intravenously every 8 hours
  • Dosage adjustments for special populations such as renal impairment, hepatic impairment, and elderly patients

Administration

  • Administered by intravenous infusion over approximately 15-30 minutes or as intravenous bolus over 3-5 minutes

Interaction

  • Potential interaction with probenecid affecting renal excretion and plasma concentration
  • May reduce serum valproic acid levels

Contraindications

  • Contraindicated in patients with demonstrated hypersensitivity to the product

Side Effects

  • Inflammation and pain at the injection site
  • Skin reactions such as rash and pruritus
  • Gastrointestinal effects like abdominal pain, nausea, vomiting, and diarrhea
  • Headache

Pregnancy & Lactation

  • Pregnancy Category B
  • Caution advised when administered to nursing women due to potential excretion in human milk

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Careful monitoring in patients with hepatic disease

Use in Special Populations

  • Dosage adjustments for renal impairment, hepatic impairment, elderly patients, and children
  • Efficacy and tolerability not established in infants under 3 months

Overdose Effects

  • Accidental overdose may occur in patients with renal impairment
  • Symptomatic treatment recommended
  • Haemodialysis for removal in subjects with renal impairment

Therapeutic Class

  • Belongs to the class of other beta-lactam antibiotics

Reconstitution

  • Preparation of solution for intravenous bolus and infusion administration
  • Recommended compatible infusion fluids for intravenous infusion

Storage Conditions

  • Store vial in a cool, dry place below 30°C, away from light and moisture

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