Fulspec 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 720.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Acme laboratories ltd
Also available as
Fulspec 1 gm injection Fulspec 250 mg injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Exerts bactericidal action by interfering with bacterial cell wall synthesis

Dosage

  • Adults:
    • 500 mg to 1 gm by intravenous administration every 8 hours
    • Different dosage for specific infections
  • Children:
    • 10 to 40 mg/kg intravenously every 8 hours
    • Different dosage for specific infections

Administration

Administered by intravenous infusion or as intravenous bolus

Interaction

  • Competes with Probenecid for active tubular secretion
  • May reduce serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B. Limited studies in pregnant women. Caution advised for nursing women

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Monitor transaminase and bilirubin levels in patients with hepatic disease

Use in Special Populations

  • Renal impairment: Dosage reduction for patients with creatinine clearance less than 51 ml/min
  • Hepatic impairment: No dosage adjustments needed for liver function impairment
  • Elderly: No dosage adjustments needed unless creatinine clearance is <51 ml/min
  • Use in Children: Efficacy and tolerability in infants under 3 months not established

Overdose Effects

Accidental overdose could occur, treatment should be symptomatic

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration: Reconstitute with sterile water for injection
  • Intravenous infusion administration: Constitute with compatible infusion fluids and dilute as needed
  • Compatible infusion fluids:
    • 0.9% sodium chloride
    • 5% or 10% glucose
    • 5% glucose with 0.02% sodium bicarbonate
    • 5% glucose and 0.9% sodium chloride
    • 5% glucose with 0.225% sodium chloride
    • 5% glucose with 0.15% potassium chloride
    • 2.5% and 10% mannitol
    • normosol-M in 5% glucose
  • Stability: Maintains potency for up to 3 hours at up to 25°C or 13 hours at up to 5°C

Storage Conditions

Store in a cool, dry place below 30°C, away from light & moisture

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