I-Penam 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 700.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Incepta pharmaceuticals ltd
Also available as
I penam 1 gm injection I penam 250 mg injection

Indications

  • Treatment of Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

  • Bactericidal action by interfering with bacterial cell wall synthesis
  • Potent bactericidal activity against a broad spectrum of bacteria

Dosage

  • Administered intravenously
  • Dosage recommended for adults and children
  • Range of dosages based on the type and severity of infection

Administration

  • Intravenous infusion over approximately 15-30 minutes
  • Intravenous bolus over approximately 3-5 minutes

Interaction

  • Competes with probenecid for active tubular secretion
  • May reduce serum valproic acid levels

Contraindications

  • Hypersensitivity to the product

Side Effects

  • Inflammation at the site of injection
  • Thrombophlebitis
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

  • Pregnancy Category B
  • Use during pregnancy only if clearly needed
  • Caution when administered to nursing women

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Careful monitoring in patients with hepatic disease

Use in Special Populations

  • Dosage adjustments for renal impairment
  • No dosage adjustments necessary in hepatic impairment
  • No dosage adjustments necessary in elderly patients unless creatinine clearance is <51 ml/min
  • Efficacy and tolerability in infants under 3 months not established

Overdose Effects

  • Accidental overdose could occur, particularly in patients with renal impairment
  • Symptomatic treatment of overdose
  • Rapid renal elimination in normal individuals
  • Haemodialysis for removal in subjects with renal impairment

Therapeutic Class

  • Belongs to other beta-lactam Antibiotics

Reconstitution

  • Preparation of intravenous bolus and infusion
  • Compatible with various infusion fluids
  • Maintains potency for up to 3 hours at up to 25°C or 13 hours at up to 5°C

Storage Conditions

  • Store below 30°C, away from light & moisture
  • Keep out of the reach of children

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