Merobac 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 652.45

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Popular pharmaceuticals ltd
Also available as
Merobac 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action interference with bacterial cell wall synthesis, potent activity against Gram-positive and Gram-negative bacteria

Dosage

  • Adults:
    • 500 mg to 1 gm intravenous administration every 8 hours
    • Specific dosages for different infections
  • Children:
    • 10 to 40 mg/kg intravenously every 8 hours for 3 months to 12 years
    • Specific dosages for different infections

Administration

Intravenous Infusion over approximately 15-30 minutes or intravenous bolus over approximately 3-5 minutes

Interaction

  • Probenecid competition for active tubular secretion
  • Reduced serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B, caution during breastfeeding

Precautions & Warnings

  • Allergic reaction precautions
  • Monitoring of transaminase and bilirubin levels in hepatic disease

Use in Special Populations

  • Dosage adjustment in renal impairment
  • No dosage adjustment in hepatic impairment
  • Hemodialysis recommendation for hemodialysis patients
  • Efficacy and tolerability in infants under 3 months not established

Overdose Effects

Symptomatic treatment, hemodialysis in renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration: Reconstitution with sterile water for injection
  • Intravenous infusion administration: Direct constitution with compatible infusion fluid and further dilution
  • Compatibility with infusion fluids:
    • 0.9% sodium chloride intravenous infusion
    • 5% or 10% glucose intravenous infusion
    • More compatible fluids

Storage Conditions

Store in a cool, dry place below 30°C, away from light and moisture

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