Merobac 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,204.53

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Popular pharmaceuticals ltd
Also available as
Merobac 500 mg injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action by interfering with bacterial cell wall synthesis

Dosage

  • Adults:
    • Usual dose of 500 mg to 1 gm by intravenous administration every 8 hours
    • Varied dosage based on specific infections
  • Children:
    • Dosage based on age, type and severity of infection, and patient's condition

Administration

  • Intravenous Infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes

Interaction

  • Probenecid competes with Merobac for active tubular secretion and thus inhibits the renal excretion

Contraindications

  • Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B. Caution advised during lactation

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Careful monitoring in hepatic disease

Use in Special Populations

  • Renal impairment: Dosage should be reduced in patients with creatinine clearance less than 51 ml/min
  • Hepatic impairment: No dosage adjustments necessary
  • Elderly: No dosage adjustments necessary
  • Children: Efficacy and tolerability in infants under 3 months not established

Overdose Effects

Symptomatic treatment recommended

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration
  • Intravenous infusion administration
  • Compatible infusion fluids

Storage Conditions

Store in a cool, dry place below 30°C, away from light and moisture

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