Merocar 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 650.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Globe pharmaceuticals ltd
Also available as
Merocar 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Carbapenem antibiotic for parenteral use, interferes with bacterial cell wall synthesis, penetrates bacterial cell walls, stable against serine beta-lactamases, affinity for Penicillin Binding Proteins, potent bactericidal activity against broad spectrum of bacteria

Dosage

  • Adults:
    • 500 mg to 1 gm by intravenous administration every 8 hours
    • 1 g IV every 8 hours for nosocomial pneumonias, peritonitis, presumed infections in neutropenic patients and septicaemia
    • Upto 2 gm every 8 hours for cystic fibrosis
    • 2 gm IV every 8 hours for meningitis
  • Children:
    • 10 to 40 mg/kg intravenously every 8 hours depending on type and severity of infection
    • 20 mg/kg every 8 hours for intra-abdominal infections
    • 25-40 mg/kg every 8 hours for cystic fibrosis
    • 40 mg/kg IV every 8 hours for meningitis
    • 20 mg/kg every 8 hours for febrile neutropenia

Administration

Intravenous Infusion over approximately 15-30 minutes or as intravenous bolus (5 to 20 ml) over approximately 3-5 minutes

Interaction

Competes with Merocar for active tubular secretion, inhibits renal excretion, may reduce serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B, caution during nursing

Precautions & Warnings

Discontinue if allergic reaction occurs, careful monitoring in patients with hepatic disease

Use in Special Populations

  • Dosage reduction in patients with creatinine clearance less than 51 ml/min
  • No dosage adjustments necessary with impairment of liver function
  • No dosage adjustments necessary in elderly patients unless creatinine clearance is <51 ml/min
  • Infants under 3 months' efficacy and tolerability not established

Overdose Effects

Symptomatic treatment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

Intravenous bolus Administration: Reconstitute with sterile water for injection, Intravenous infusion administration: Constituted with compatible infusion fluid and then further diluted, Potency maintained for up to 3 hours at up to 25°C or 13 hours at up to 5°C

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture

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