Merocar 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,200.00

Medicine Details

Category	Details
Generic	Meropenem trihydrate
Company	Globe pharmaceuticals ltd
Also available as	Merocar 500 mg injection

Indications

Pneumonia and Nosocomial Pneumonia
Urinary Tract Infections
Intra-abdominal Infections
Gynaecological Infections
Skin and Skin Structure Infections
Meningitis
Septicaemia
Pulmonary infections in cystic fibrosis
Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Exerts bactericidal action by interfering with bacterial cell wall synthesis and shows potent activity against a broad spectrum of bacteria.

Dosage

Adults:
- 500 mg to 1 gm by intravenous administration every 8 hours
- varied doses for specific infections
Children:
- 10 to 40 mg/kg intravenously every 8 hours
- varied doses for specific infections

Administration

Should be administered by intravenous infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes

Interaction

Competes with probenecid for active tubular secretion
May reduce serum valproic acid levels

Contraindications

Contraindicated in patients with demonstrated hypersensitivity to the product

Side Effects

Inflammation
Thrombophlebitis
Pain at injection site
Skin reactions like rash, pruritus, urticaria
Abdominal pain
Nausea
Vomiting
Diarrhea
Headache

Pregnancy & Lactation

Pregnancy Category B; should be used during pregnancy only if clearly needed. Caution should be exercised when administered to a nursing woman.

Precautions & Warnings

Discontinue if allergic reaction occurs
Use with careful monitoring in patients with hepatic disease

Use in Special Populations

Renal impairment: Dosage should be reduced in patients with creatinine clearance less than 51 ml/min
Hepatic impairment: No dosage adjustments necessary
Elderly: No dosage adjustments necessary unless creatinine clearance is less than 51 ml/min
Efficacy and tolerability in infants under 3 months not established

Overdose Effects

Accidental overdose could occur, treatment should be symptomatic; rapid renal elimination will occur in normal individuals, haemodialysis needed in subjects with renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

Preparation of solution for intravenous bolus and infusion administration, compatibility with various infusion fluids

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture; keep out of the reach of children.