Merom 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 600.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Techno drugs ltd
Also available as
Merom 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Exerts bactericidal action by interfering with bacterial cell wall synthesis, penetrates bacterial cell walls, stable against serine beta-lactamases, shows potent bactericidal activity against broad spectrum of bacteria.

Dosage

  • Adults:
    • Usual dose is 500 mg to 1 gm by intravenous administration every 8 hours
    • Higher doses for specific infections like pneumonia, urinary tract infections, gynaecological infections, nosocomial pneumonias, peritonitis, cystic fibrosis, and meningitis
  • Children:
    • Dosage varies based on age and infection type
    • No experience in children with hepatic or renal impairment

Administration

Administered by intravenous infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes

Interaction

Potential interaction with probenecid, which can inhibit renal excretion and increase plasma concentration, may reduce serum valproic acid levels

Contraindications

Contraindicated in patients with demonstrated hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Category B; caution advised during pregnancy and lactation

Precautions & Warnings

  • Discontinue in case of allergic reaction
  • Careful monitoring in patients with hepatic disease

Use in Special Populations

  • Renal impairment: Dosage should be reduced in patients with creatinine clearance less than 51 ml/min
  • Hepatic impairment: No dosage adjustments necessary
  • Elderly: No dosage adjustments necessary unless creatinine clearance is <51 ml/min
  • Children: Efficacy and tolerability in infants under 3 months not established

Overdose Effects

Accidental overdose could occur, treatment should be symptomatic; rapid renal elimination in normal individuals, hemodialysis in subjects with renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration: Reconstitute with sterile water for injection, shake to dissolve
  • Intravenous infusion administration: May be directly constituted with compatible infusion fluid and further diluted as needed, compatible with specific infusion fluids, use freshly reconstituted solution

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture, keep out of the reach of children

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