Meromax 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,250.00

Medicine Details

Category	Details
Generic	Meropenem trihydrate
Company	Orion pharma ltd
Also available as	Meromax 500 mg injection

Indications

Pneumonia and Nosocomial Pneumonia
Urinary Tract Infections
Intra-abdominal Infections
Gynaecological Infections
Skin and Skin Structure Infections
Meningitis
Septicaemia
Pulmonary infections in cystic fibrosis
Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Meropenem is a carbapenem antibiotic for parenteral use. It exerts its bactericidal action by interfering with bacterial cell wall synthesis. It penetrates bacterial cell walls and shows potent bactericidal activity against a broad spectrum of bacteria.

Dosage

Adults:
- 500 mg to 1 gm by intravenous administration every 8 hours
- 1 g IV every 8 hours for nosocomial pneumonias, peritonitis, presumed infections in neutropenic patients, and septicaemia
Children:
- 10 to 40 mg/kg intravenously every 8 hours depending on type and severity of infection
- 20 mg/kg every 8 hours for intra-abdominal infections

Administration

Meropenem should be administered by intravenous infusion over approximately 15-30 minutes or as intravenous bolus (5 to 20 ml) over approximately 3-5 minutes.

Interaction

Probenecid competes with Meromax for active tubular secretion and thus inhibits the renal excretion, increasing the elimination half-life and plasma concentration of meropenem

Contraindications

Meropenem is contraindicated in patients who have demonstrated hypersensitivity to this product.

Side Effects

Inflammation
Thrombophlebitis
Pain at the site of injection
Skin reactions like rash, pruritus, urticaria
Abdominal pain
Nausea
Vomiting
Diarrhea
Headache

Pregnancy & Lactation

Pregnancy Category B. Caution should be exercised when Meropenem is administered to a nursing woman.

Precautions & Warnings

If an allergic reaction to Meromax occurs, the drug should be discontinued and appropriate measures taken
Use of Meromax in patients with hepatic disease should be made with careful monitoring of transaminase and bilirubin levels

Use in Special Populations

Renal impairment: Dosage should be reduced in patients with creatinine clearance less than 51 ml/min
Hepatic impairment: No dosage adjustments are necessary with impairment of liver function
Elderly: No dosage adjustments are necessary in elderly patients unless creatinine clearance is <51 ml/min
Children: Efficacy and tolerability in infants under 3 months have not been established

Overdose Effects

Accidental overdose could occur during therapy, particularly in patients with renal impairment. Treatment of overdose should be symptomatic.

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

Intravenous bolus Administration: Reconstitute Meromax (500 mg or 1 g) with sterile water for injection
Intravenous infusion administration: Meromax for intravenous infusion may be directly constituted with a compatible infusion fluid and then further diluted with the compatible infusion fluid

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.