Meropen 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 700.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Renata limited
Also available as
Meropen 1 gm injection Meropen 250 mg injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action by interfering with bacterial cell wall synthesis

Dosage

  • Adults:
    • 500 mg to 1 gm every 8 hours
    • Based on infection type and severity
  • Children:
    • 10 to 40 mg/kg every 8 hours
    • Dependent on infection type and severity

Administration

  • Intravenous Infusion over approximately 15-30 minutes or Intravenous bolus over approximately 3-5 minutes

Interaction

  • Probenecid competition for active tubular secretion
  • Potential reduction of serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the injection site
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B, Caution during lactation

Precautions & Warnings

  • Discontinue in case of allergic reaction
  • Careful use in patients with hepatic disease

Use in Special Populations

  • Dosage reduction in renal impairment
  • No adjustment for hepatic impairment
  • No dosage adjustment in elderly unless creatinine clearance is <51 ml/min
  • Efficacy not established in infants under 3 months

Overdose Effects

Symptomatic treatment, hemodialysis in cases of renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration: Reconstitute with sterile water for injection
  • Intravenous infusion administration: May be constituted with a compatible infusion fluid and then further diluted
  • Compatibility with infusion fluids:
    • 0.9% sodium chloride
    • 5% or 10% glucose with/without additives
    • 5% glucose with 0.15% potassium chloride
    • 2.5% and 10% mannitol
    • Normosol-M in 5% glucose
  • Reconstitution Stability: Up to 3 hours at up to 25°C or 13 hours at up to 5°C

Storage Conditions

Store in a cool, dry place below 30°C, away from light & moisture

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