Neopenem 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 750.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Healthcare pharmaceuticals ltd
Also available as
Neopenem 1 gm injection Neopenem 250 mg injection

Title

Neopenem

Categories

  • Medicine
  • Antibiotic
  • Infectious Disease

Description

Neopenem is an antibiotic indicated for the treatment of various infections caused by bacteria sensitive to Neopenem. It exerts its bactericidal action by interfering with bacterial cell wall synthesis.

Indications

  • Pneumonia
  • Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Meropenem is a carbapenem antibiotic with potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative bacteria.

Dosage

  • Adults:
    • 500mg to 1g IV every 8 hours for various infections
    • Up to 2g IV every 8 hours for cystic fibrosis
  • Children:
    • 10 to 40mg/kg IV every 8 hours for different infections
    • 25-40mg/kg IV every 8 hours for cystic fibrosis

Administration

  • Intravenous infusion over 15-30 minutes
  • Intravenous bolus over 3-5 minutes

Interaction

  • Competes with Probenecid for active tubular secretion
  • May reduce serum valproic acid levels

Contraindications

  • Hypersensitivity to Meropenem

Side effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Rash
  • Pruritus
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy lactation

  • Pregnancy category: B
  • Usage caution: Use during pregnancy only if clearly needed. Caution in nursing women.

Precautions warnings

  • Discontinue if allergic reaction occurs
  • Use with careful monitoring in patients with hepatic disease

Special populations

  • Renal impairment: Dosage reduction for creatinine clearance <51 ml/min
  • Hepatic impairment: No dosage adjustments needed
  • Elderly: No dosage adjustments unless creatinine clearance is <51 ml/min
  • Use in children: Efficacy and tolerability not established in infants under 3 months

Overdose effects

Symptomatic treatment for accidental overdose, haemodialysis in renal impairment

Therapeutic class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus: Reconstitute with sterile water for injection
  • Intravenous infusion: Compatible with various infusion fluids

Storage conditions

Store vial below 30°C, away from light & moisture

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