Neopenem 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,350.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Healthcare pharmaceuticals ltd
Also available as
Neopenem 500 mg injection Neopenem 250 mg injection

Title

  • Neopenem

Categories

  • Antibiotic
  • Medication
  • Pharmaceutical

Description

  • Bactericidal action by interfering with bacterial cell wall synthesis
  • Potent activity against a broad spectrum of Gram-positive and Gram-negative bacteria
  • Treatment of pneumonia, urinary tract infections, gynaecological and intra-abdominal infections, meningitis, and septicaemia
  • Dosage and duration of therapy depending on infection type and severity
  • Administered by intravenous infusion or bolus
  • Interaction with probenecid and valproic acid
  • Contraindicated in patients with hypersensitivity
  • Possible side effects including inflammation, thrombophlebitis, skin reactions, abdominal pain, nausea, vomiting, diarrhea, and headache
  • Caution advised during pregnancy and lactation
  • Precautions for allergic reactions and hepatic disease
  • Dosage adjustments for renal impairment
  • No dosage adjustments necessary for hepatic impairment and elderly patients
  • Overdose effects and treatment
  • Therapeutic class as other beta-lactam antibiotics
  • Reconstitution instructions for intravenous administration
  • Compatible infusion fluids for intravenous infusion
  • Storage conditions below 30°C, away from light and moisture

Indications

  • Effective for pneumonia, urinary tract infections, and intra-abdominal infections
  • Treatment for gynaecological infections, skin and skin structure infections, meningitis, septicaemia, and cystic fibrosis
  • Empiric treatment for presumed infections in febrile neutropenic patients

Pharmacology

  • Carbapenem antibiotic for parenteral use
  • Exerts bactericidal action by interfering with bacterial cell wall synthesis
  • Potent bactericidal activity against Gram-positive and Gram-negative bacteria

Dosage

  • Recommended daily dosage for adults and children
  • Different doses for various infections including pneumonia, urinary tract infections, gynaecological infections, intra-abdominal infections, and cystic fibrosis
  • Special dosage considerations for meningitis, febrile neutropenia, and different age groups

Administration

  • Intravenous infusion over approximately 15-30 minutes
  • Intravenous bolus over approximately 3-5 minutes

Interaction

  • Competes with probenecid for active tubular secretion
  • May reduce serum valproic acid levels

Contraindications

  • Hypersensitivity to the product

Side effects

  • Possible side effects include inflammation, thrombophlebitis, and skin reactions

Pregnancy lactation

  • Pregnancy Category B
  • Caution during lactation

Precautions warnings

  • Discontinue drug if allergic reaction occurs
  • Careful monitoring in patients with hepatic disease

Special population

  • Dosage adjustments for renal impairment
  • No dosage adjustments necessary for hepatic impairment and elderly patients
  • Efficacy and tolerability not established in infants under 3 months

Overdose effects

  • Accidental overdose potential, especially in renal impairment
  • Symptomatic treatment for overdose

Reconstitution

  • Reconstitution for intravenous bolus and infusion administration
  • Recommended compatible infusion fluids

Storage conditions

  • Store in a cool, dry place below 30°C, away from light and moisture

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