Ropenem 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 560.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Drug international ltd
Also available as
Ropenem 1 gm injection

Title

  • Ropenem Carbapenem Antibiotic

Categories

  • Pharmaceuticals
  • Antibiotics
  • Medicine
  • Healthcare

Description

  • Indicated for treatment of pneumonia, urinary tract infections, intra-abdominal infections, gynaecological infections, skin and skin structure infections, meningitis, septicaemia, pulmonary infections in cystic fibrosis, and more
  • Bactericidal action by interfering with bacterial cell wall synthesis
  • Recommended daily dosage for adults and children
  • Administration by intravenous infusion or bolus
  • Interaction with probenecid and valproic acid
  • Contraindications for patients with hypersensitivity
  • Side effects like inflammation, thrombophlebitis, pain at the site of injection, skin reactions, abdominal pain, nausea, vomiting, diarrhea, headache
  • Pregnancy category B, caution during lactation
  • Precautions for allergic reactions, hepatic disease
  • Dosage adjustments for renal impairment, hepatic impairment, and elderly
  • Overdose effects and treatment
  • Therapeutic class of other beta-lactam antibiotics
  • Reconstitution and compatible infusion fluids
  • Storage conditions below 30°C, away from light & moisture

Indications

  • Pneumonia
  • Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Endometritis
  • Pelvic Inflammatory Disease
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary Infections in Cystic Fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

  • Bactericidal action by interfering with bacterial cell wall synthesis
  • Potent activity against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria

Dosage

  • Recommended daily dosage for adults
  • Recommended daily dosage for children
  • Dosage adjustments for different types of infections and patient conditions

Administration

  • Intravenous infusion over approximately 15-30 minutes
  • Intravenous bolus over approximately 3-5 minutes

Interaction

  • Competes with probenecid for active tubular secretion
  • Reduces serum valproic acid levels

Contraindications

  • Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

  • Pregnancy Category B
  • Caution during lactation

Precautions & Warnings

  • Allergic reaction precautions
  • Careful monitoring for patients with hepatic disease

Use in Special Populations

  • Dosage adjustments for renal impairment
  • Dosage adjustments for hepatic impairment
  • No dosage adjustments necessary in elderly patients
  • Efficacy and tolerability in infants under 3 months not established

Overdose Effects

  • Accidental overdose in patients with renal impairment
  • Symptomatic treatment
  • Renal elimination
  • Haemodialysis for patients with renal impairment

Therapeutic Class

  • Other beta-lactam antibiotics

Reconstitution

  • Intravenous bolus administration
  • Intravenous infusion administration
  • Compatible infusion fluids
  • Recommended use of freshly reconstituted solution
  • Potency maintenance at specific temperatures

Storage Conditions

  • Store in a cool, dry place (below 30°C)
  • Away from light & moisture

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