Specbac 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,300.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Square pharmaceuticals plc
Also available as
Specbac 500 mg injection Specbac 250 mg injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Meropenem is a carbapenem antibiotic for parenteral use. It exerts its bactericidal action by interfering with bacterial cell wall synthesis. It penetrates bacterial cell walls and shows potent bactericidal activity against a broad spectrum of bacteria.

Dosage

  • Adults:
    • 500 mg to 1 gm by intravenous administration every 8 hours
    • 1 g IV every 8 hours for Nosocomial pneumonias, peritonitis, presumed infections in neutropenic patients and septicaemia
    • Upto 2 gm every 8 hours for Cystic fibrosis
    • 2 gm IV every 8 hours for Meningitis
  • Children:
    • 10 to 40 mg/kg intravenously every 8 hours
    • 20 mg/kg every 8 hours for Intra-abdominal infections
    • 25-40 mg/kg every 8 hours for Cystic fibrosis (4-18 years)
    • 40 mg/kg IV every 8 hours for Meningitis
    • 20 mg/kg every 8 hours for Febrile neutropenia

Administration

Meropenem should be administered by intravenous Infusion over approximately 15-30 minutes or as intravenous bolus (5 to 20 ml) over approximately 3-5 minutes

Interaction

  • Probenecid competes with Specbac for active tubular secretion
  • Reduced serum valproic acid levels

Contraindications

Meropenem is contraindicated in patients with demonstrated hypersensitivity to this product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B. Caution should be exercised when Meropenem is administered to a nursing woman

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Careful monitoring of transaminase and bilirubin levels in patients with hepatic disease

Use in Special Populations

  • Dosage adjustment for renal impairment
  • No dosage adjustments necessary in hepatic impairment
  • No dosage adjustments necessary in elderly patients
  • Efficacy and tolerability in infants under 3 months not established

Overdose Effects

Symptomatic treatment for accidental overdose

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

Specbac may be reconstituted with sterile water for injection for intravenous bolus administration or with compatible infusion fluids for intravenous infusion administration

Storage Conditions

Vial should be stored in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.

Related Brands