Intrapen 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,350.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company General pharmaceuticals ltd
Also available as
Intrapen 500 mg injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Meropenem is a carbapenem antibiotic for parenteral use. It exerts its bactericidal action by interfering with bacterial cell wall synthesis, penetrating bacterial cell walls, showing potent bactericidal activity against a broad spectrum of bacteria.

Dosage

  • Adults:
    • Usual dose is 500 mg to 1 gm by intravenous administration every 8 hours
    • Dosage varies for different infections
  • Children:
    • Dosage varies by age and type of infection
    • No experience in children with hepatic or renal impairment

Administration

Meropenem should be administered by intravenous infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes.

Interaction

Probenecid competes with Intrapen for active tubular secretion and may inhibit renal excretion, leading to increased plasma concentration of meropenem. Intrapen may reduce serum valproic acid levels.

Contraindications

Meropenem is contraindicated in patients with demonstrated hypersensitivity to this product.

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B, caution should be exercised when administered to a nursing woman.

Precautions & Warnings

If an allergic reaction occurs, the drug should be discontinued. Use in patients with hepatic disease should be monitored carefully.

Use in Special Populations

  • Dosage should be reduced in patients with renal impairment
  • No dosage adjustments are necessary in patients with hepatic impairment
  • No dosage adjustments are necessary in elderly patients unless creatinine clearance is less than 51 ml/min
  • Efficacy and tolerability in infants under 3 months have not been established

Overdose Effects

Symptomatic treatment of overdose is recommended.

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

Intrapen for intravenous infusion may be directly constituted with a compatible infusion fluid and then further diluted as needed. The use of freshly reconstituted solution is recommended, and it maintains potency for a specified duration at specified temperatures.

Storage Conditions

Vial should be stored in a cool, dry place (below 30°C), away from light and moisture, and out of the reach of children.

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