Merocil 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,594.78

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Pharmacil limited
Also available as
Merocil 500 mg injection Merocil 250 mg injection

Product Name

  • Meropenem

Category

  • Antibiotic
  • Medication

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

  • Bactericidal action by interfering with bacterial cell wall synthesis
  • Potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria

Dosage

  • Dosage and duration established depending on type and severity of infection
  • Recommended daily dosage for adults and children
  • Intravenous administration every 8 hours
  • Intravenous Infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes

Administration

  • Administered by intravenous Infusion
  • Administered as intravenous bolus

Interaction

  • Competes with Meropenem for active tubular secretion
  • Inhibits renal excretion
  • May reduce serum valproic acid levels

Contraindications

  • Hypersensitivity to this product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

  • Pregnancy Category B
  • No adequate and well-controlled studies in pregnant women
  • Caution when administered to a nursing woman

Precautions & Warnings

  • Allergic reaction
  • Discontinuation in case of allergic reaction
  • Careful monitoring in patients with hepatic disease

Use in Special Populations

  • Dosage adjustment in patients with renal impairment
  • No dosage adjustments in elderly patients
  • Efficacy and tolerability in infants under 3 months not established

Overdose Effects

  • Accidental overdose could occur during therapy
  • Symptomatic treatment of overdose
  • Rapid renal elimination in normal individuals
  • Haemodialysis in subjects with renal impairment

Therapeutic Class

  • Other beta-lactam Antibiotics

Reconstitution

  • Preparation of solution for intravenous bolus Administration
  • Preparation of solution for intravenous infusion administration
  • Compatible with various infusion fluids
  • Freshly reconstituted solution recommended
  • Maintains potency for up to 3 hours at up to 25°C or 13 hours at up to 5°C

Storage Conditions

  • Store in a cool, dry place below 30°C
  • Away from light and moisture
  • Keep out of the reach of children

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