Dorinem 500 mg/vial (IV Infusion)

500 mg vial: ৳ 2,006.00

Medicine Details

Category Details
Generic Doripenem
Company Aci limited

Indications

  • Treatment of complicated intra-abdominal infections
  • Treatment of complicated urinary tract infections including pyelonephritis

Pharmacology

Synthetic broad-spectrum carbapenem β-lactam antibiotic with potent in vitro antibacterial activity

Dosage & Administration

  • Intravenous:
    • 500 mg 8 hrly infused over 1 hr for 5-14 days for complicated intra-abdominal infections
    • 500 mg 8 hrly infused over 1 hr for 10 days for complicated UTI, Pyelonephritis
    • Duration can be extended up to 14 days for patients with concurrent bacteremia
  • Renal Impairment:
    • CrCI (30-50 ml/min): 250 mg every 8 hr by IV infusion over 1 hr
    • CrCI (11 -29 ml/min): 250 mg every 12 hr by IV infusion over 1 hr

Interaction

Increased plasma concentration with probenecid. May decrease plasma levels of valproic acid.

Contraindications

  • Hypersensitivity to doripenem
  • History of anaphylactic reaction to β-lactams

Side Effects

  • Headache
  • Nausea
  • Diarrhoea
  • Rash
  • Pruritus
  • Phlebitis
  • Elevated hepatic enzymes

Pregnancy & Lactation

Pregnancy Category B. No controlled studies in pregnant women.

Precautions & Warnings

  • Not intended for treatment of any type of pneumonia
  • Renal impairment
  • Patient with known or suspected CNS disorders

Therapeutic Class

Other beta-lactam Antibiotics

Storage Conditions

Reconstituted suspension may be held for 1 hr prior to dilution in infusion bag. Following dilution of the suspension with NaCl 0.9%, stability is 8 hr at room temperature or 24 hr between 2-8°C.

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