Dorinem 500 mg/vial (IV Infusion)
500 mg vial: ৳ 2,006.00
Medicine Details
Category | Details |
---|---|
Generic | Doripenem |
Company | Aci limited |
Indications
- Treatment of complicated intra-abdominal infections
- Treatment of complicated urinary tract infections including pyelonephritis
Pharmacology
Synthetic broad-spectrum carbapenem β-lactam antibiotic with potent in vitro antibacterial activity
Dosage & Administration
- Intravenous:
- 500 mg 8 hrly infused over 1 hr for 5-14 days for complicated intra-abdominal infections
- 500 mg 8 hrly infused over 1 hr for 10 days for complicated UTI, Pyelonephritis
- Duration can be extended up to 14 days for patients with concurrent bacteremia
- Renal Impairment:
- CrCI (30-50 ml/min): 250 mg every 8 hr by IV infusion over 1 hr
- CrCI (11 -29 ml/min): 250 mg every 12 hr by IV infusion over 1 hr
Interaction
Increased plasma concentration with probenecid. May decrease plasma levels of valproic acid.
Contraindications
- Hypersensitivity to doripenem
- History of anaphylactic reaction to β-lactams
Side Effects
- Headache
- Nausea
- Diarrhoea
- Rash
- Pruritus
- Phlebitis
- Elevated hepatic enzymes
Pregnancy & Lactation
Pregnancy Category B. No controlled studies in pregnant women.
Precautions & Warnings
- Not intended for treatment of any type of pneumonia
- Renal impairment
- Patient with known or suspected CNS disorders
Therapeutic Class
Other beta-lactam Antibiotics
Storage Conditions
Reconstituted suspension may be held for 1 hr prior to dilution in infusion bag. Following dilution of the suspension with NaCl 0.9%, stability is 8 hr at room temperature or 24 hr between 2-8°C.