Oramycin 500 mg (Tablet)

Title

• Oramycin

Categories

• Antibiotics
• Anti-Infectives
• Tetracycline Drugs

Description

• Primarily a bacteriostatic broad-spectrum antibiotic
• Wide spectrum of activity against Gram-positive and Gram-negative microorganisms
• Acts as an antimicrobial agent by inhibiting bacterial protein synthesis
• Effective against parasites such as rickettsia, mycoplasma, chlamydia and amoeba

Indications

• Respiratory tract infections
• Mycoplasma pneumonia
• Urinary tract infections
• Infections due to Chlamydia trachomatis
• Uncomplicated urethral, endocervical or rectal infections
• Non-gonococcal urethritis
• Chancroid
• Granuloma inguinale
• Lymphogranuloma venereum
• Gonorrhea
• Syphilis
• Skin infections: Acne and rosacea
• Ophthalmic infections: Trachoma
• Rickettsial infections
• Other infections: Psittacosis, brucellosis, cholera, acute intestinal amoebiasis

Pharmacology

• Mechanism of action: Inhibits cell growth by inhibiting translation
• Binds to the 30S ribosomal subunit
• Prevents the amino-acyl tRNA from binding to the A site of the ribosome
• Lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane

Dosage & Administration

• Adults: 250-500 mg every 6 hours
• Tetracyclines should be given one hour before or two hours after meals to avoid interference with food, milk, and some dairy products

Interactions

• Antacids containing Aluminium, Calcium, Magnesium, Zinc, or Iron salts may impair the absorption of Oramycin
• Long term therapy may depress plasma prothrombin activity and require reduced doses of concomitant anticoagulants
• Concurrent use with oral contraceptives may lead to pregnancy or breakthrough bleeding

Contraindications

• Hypersensitivity to Tetracyclines
• Children under 12 years of age
• Pregnancy due to possible tooth staining in the fetus and growth retardation effects

Side Effects

• Anorexia
• Nausea
• Vomiting
• Diarrhea
• Glossitis
• Skin rashes
• Urticaria

Pregnancy & Lactation

• Crosses the placenta and can have toxic effects on the developing fetus
• Embryotoxicity noted in animals treated early in pregnancy
• Present in the milk of lactating women taking this drug

Precautions & Warnings

• Caution in renal impairment

Therapeutic Class

• Eye Anti-Infectives & Antiseptics
• Tetracycline group of drugs
• Topical antibiotics for Acne

Storage Conditions

• Keep below 30°C temperature
• Away from light & moisture
• Keep out of the reach of children

Related Brands