Bpdox 100 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxycycline hydrochloride |
| Company | Bristol pharmaceuticals ltd |
Indications
- Respiratory tract infections
- Gastrointestinal tract infections
- Chlamydial infections
- Sexually transmitted diseases
- Impetigo
- Furunculosis
- Inclusion conjunctivitis
- Brucellosis
- Tularemia
- Cellulitis
- Acne
- Q-fever
Description
Highly active broad-spectrum antibiotic of tetracycline group effective against Gram-positive and Gram-negative bacteria, spirochete, mycoplasma, rickettsia, and mycobacteria. Used as an alternate to penicillin in the treatment of gonorrhoea and syphilis. Main mechanism of action is on protein synthesis.
Pharmacology
- Semisynthetic tetracycline antibiotic with broad spectrum activity
- Primarily a bacteriostatic antibiotic
- More active against Staphylococcus aureus and Nocardia
- Active against penicillin-resistant strains of Staphylococcus aureus
- Active against certain Gram-negative strains like E. coli and Proteus mirabilis
- Active against Haemophilus influenzae, H. ducreyi, Actinomyces, Brucella, and Vibrio cholerae
- Active against Nocardia, Chlamydia, Mycoplasma, and a wide range of Rickettsiae
- Active against spirochetes like Borellia recurrentis and Treponema pertenue
- Active against Plasmodium falciparum
Dosage
- Usual dose of 200 mg on first day, then 100 mg daily for 7-10 days
- Severe infections: 200 mg daily for 10 days
- Acne: 100 mg daily
- Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days
Administration
Capsules should be swallowed whole with plenty of fluid during meals while sitting or standing.
Interaction
- Absorption impaired by antacids containing aluminium, calcium or magnesium
- Absorption impaired by bismuth salicylate
- Barbiturates, carbamazepine, and phenytoin decrease half-life
- Concurrent use may render oral contraceptives less effective
- May require downward adjustment of anticoagulant dosages
Contraindications
- Hypersensitivity to any tetracyclines
- Children under 8 years of age
- Pregnant and lactating women
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Skin rashes
- Hemolytic anaemia
- Eosinophilia
Pregnancy & Lactation
Avoid in pregnant women due to risk of staining and effect on bone growth in the fetus. Enter breast milk, so mothers taking these drugs should not breastfeed.
Precautions & Warnings
Use during tooth development may cause permanent discoloration of teeth, hence should not be used in children under 8 years.
Therapeutic Class
Tetracycline group of drugs
Storage Conditions
Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.