Dopac 100 mg (Capsule)

Indications

• Respiratory tract infections: pneumonia, influenza, sinusitis, bronchitis, tonsillitis, tracheitis
• Gastrointestinal tract infections: cholera, traveler's diarrhea, shigella dysentery, acute intestinal amebiasis
• Chlamydial infections: lympho-granuloma venereum, psittacosis, trachoma
• Sexually transmitted diseases: non-gonococcal urethritis, acute pelvic inflammatory disease, uncomplicated urethral and endocervical or rectal infections, gonorrhea, syphilis, pyelonephritis, cystitis
• Other infections: impetigo, furunculosis, inclusion conjunctivitis, brucellosis, tularemia, cellulitis, acne, Q-fever

Description

• Highly active broad-spectrum antibiotic of tetracycline group
• Effective against a wide range of Gram-positive and Gram-negative bacteria, spirochete, mycoplasma, rickettsia and mycobacteria
• Used as an alternate to penicillin in the treatment of gonorrhea and syphilis
• Main mechanism of action on protein synthesis

Pharmacology

• Semisynthetic tetracycline antibiotic with broad spectrum activity
• Bacteriostatic antibiotic
• More active against Staphylococcus aureus and Nocardia
• Active against penicillin-resistant strains of Staphylococcus aureus and other Tetracyclines resistant organisms
• Active against certain Gram-negative strains of E. coli, Proteus mirabilis, Klebsiella
• 70-90% of various anaerobes are sensitive to Doxycycline

Dosage

• Usual dose: 200 mg on first day, then 100 mg daily for 7-10 days
• Severe infections (including refractory urinary tract infections): 200 mg daily for 10 days
• Acne: 100 mg daily
• Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days (14-21 days in pelvic inflammatory disease)

Administration

Capsules should be swallowed whole with plenty of fluid during meals while sitting or standing

Interaction

• Absorption of tetracyclines impaired by antacids containing aluminum, calcium, magnesium, and iron
• Absorption of tetracyclines impaired by bismuth salicylate
• Barbiturates, carbamazepine and phenytoin decrease half-life of doxycycline
• Concurrent use of tetracyclines may render oral contraceptive less effective
• Patients on anticoagulant therapy may require downward adjustment of their anticoagulant dosages
• Avoid giving tetracyclines in conjunction with penicillin

Contraindications

• Hypersensitivity to any of the tetracyclines
• Children under 8 years of age
• Pregnant women and lactating mothers

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Skin rashes
• Hemolytic anemia
• Eosinophilia

Pregnancy & Lactation

Doxycycline should be avoided in pregnant women due to the risk of staining and effect on bone growth in the fetus. Mothers taking these drugs should not breastfeed their child.

Precautions & Warnings

The use of tetracycline class drugs during tooth development may cause permanent discoloration of teeth, therefore should not be used in children under 8 years.

Therapeutic Class

Tetracycline group of drugs

Storage Conditions

Keep all medicines out of reach of children. Store in a cool and dry place, protected from light

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