Doximet 100 mg (Capsule)
Unit Price: ৳ 2.50 (100's pack: ৳ 250.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxycycline hydrochloride |
| Company | Medimet pharmaceuticals ltd |
Indications
- Respiratory tract infections: Pneumonia, influenza, sinusitis, bronchitis, tonsillitis, tracheitis
- Gastrointestinal tract infections: Cholera, traveler's diarrhea, shigella dysentery, acute intestinal amebiasis
- Chlamydial infections: Lympho-granuloma venereum, psittacosis, trachoma
- Sexually transmitted diseases: Non gonococcal urethritis, acute pelvic inflammatory disease, uncomplicated urethral and endocervical or rectal infections, gonorrhoea, syphilis, pyelonephritis, cystitis
- Other infections: Impetigo, furunculosis, inclusion conjunctivitis, brucellosis, tularemia, cellulitis, acne, Q-fever
Description
- Highly active broad-spectrum antibiotic of tetracycline group
- Effective against a wide range of Gram-positive and Gram-negative bacteria, spirochete, mycoplasma, rickettsia, and mycobacteria
- Used as an alternate to penicillin in the treatment of gonorrhoea and syphilis
- Main mechanism of action on protein synthesis inside the bacterial cell
Pharmacology
- Semisynthetic tetracycline antibiotic with broad spectrum activity
- Primarily a bacteriostatic antibiotic
- More active against Staphylococcus aureus and Nocardia
- Active against penicillin-resistant strains of Staphylococcus aureus and certain Gram-negative strains of E. coli, Proteus mirabilis, and Klebsiella
Dosage
- Usual dose: 200 mg on the first day, then 100 mg daily for 7-10 days
- Severe infections: 200 mg daily for 10 days
- Acne: 100 mg daily
- Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days
Administration
- Capsules should be swallowed whole with plenty of fluid during meals while sitting or standing
Interaction
- Absorption of tetracyclines impaired by antacid containing aluminium, calcium, or magnesium, and iron-containing preparation
- Impaired absorption by bismuth salicylate
- Barbiturates, carbamazepine, and phenytoin decrease half-life of doxycycline
- Concurrent use of tetracyclines may render oral contraceptive less effective
- Patients on anticoagulant therapy may require downward adjustment of their anticoagulant dosages
- Avoid giving tetracyclines in conjunction with penicillin
Contraindications
- Hypersensitivity to any of the tetracyclines
- Children under 8 years of age
- Pregnant women and lactating mothers
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Skin rashes
- Hemolytic anaemia
- Eosinophilia
Pregnancy & Lactation
- Avoided in pregnant women due to the risk of staining and effect on bone growth in the foetus
- Enters breast milk, so mothers taking these drugs should not breastfeed
Precautions & Warnings
- Should not be used during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years) as it may cause permanent discoloration of teeth
Therapeutic Class
- Tetracycline group of drugs
Storage Conditions
- Keep all medicines out of reach of children
- Store in a cool and dry place, protected from light