Doxseem 100 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxycycline hydrochloride |
| Company | Seema pharmaceuticals ltd |
Indications
- Respiratory tract infections: Pneumonia, influenza, sinusitis, bronchitis, tonsillitis, tracheitis
- Gastrointestinal tract infections: Cholera, traveler's diarrhea, shigella dysentery, acute intestinal amebiasis
- Chlamydial infections: Lympho-granuloma venereum, psittacosis, trachoma
- Sexually transmitted diseases: Non gonococcal urethritis, acute pelvic inflammatory disease, uncomplicated urethral and endocervical or rectal infections, gonorrhoea, syphilis, pyelonephritis, cystitis
- Other infections: Impetigo, furunculosis, inclusion conjunctivitis, brucellosis, tularemia, cellulitis, acne, Q-fever
Description
Highly active broad-spectrum antibiotic of tetracycline group. Effective against a wide range of Gram-positive and Gram-negative bacteria, spirochete, mycoplasma, rickettsia, and mycobacteria. Used as an alternate to penicillin in the treatment of gonorrhoea and syphilis. Main mechanism of action on protein synthesis.
Pharmacology
Semi-synthetic tetracycline antibiotic with broad-spectrum activity. Primarily a bacteriostatic antibiotic. More active against Staphylococcus aureus and Nocardia. Active against penicillin-resistant strains of Staphylococcus aureus. Active against certain Gram-negative strains of E. coli, Proteus mirabilis, Klebsiella, Haemophilus influenzae, H. ducreyi, Actinomyces, Brucella, Vibrio cholerae, Nocardia, Chlamydia, Mycoplasma, Rickettsiae, spirochetes, and Plasmodium falciparum.
Dosage
Usual dose: 200 mg on first day, then 100 mg daily for 7-10 days. Severe infections: 200 mg daily for 10 days. Acne: 100 mg daily. Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days (14-21 days in pelvic inflammatory disease).
Administration
Capsules should be swallowed whole with plenty of fluid during meals while sitting or standing.
Interaction
Absorption impaired by antacids, iron-containing preparations, bismuth salicylate. Barbiturates, carbamazepine, phenytoin decrease half-life. Concurrent use may render oral contraceptives less effective. Patients on anticoagulant therapy may require downward adjustment of dosages. Avoid giving in conjunction with penicillin.
Contraindications
Hypersensitivity to tetracyclines, children under 8 years, pregnant women, lactating mothers.
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Skin rashes
- Hemolytic anaemia
- Eosinophilia
Pregnancy & Lactation
Avoid in pregnant women due to risk of staining and effect on bone growth in the foetus. Enters breast milk, mothers should not breastfeed.
Precautions & Warnings
Avoid use during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years) to prevent permanent discoloration of teeth.
Therapeutic Class
Tetracycline group of drugs
Storage Conditions
Store in a cool and dry place, protected from light, out of reach of children.