Apdox 100 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxycycline hydrochloride |
| Company | Apex pharmaceuticals ltd |
Indications
- Respiratory tract infections: Pneumonia, influenza, sinusitis, bronchitis, tonsillitis, tracheitis
- Gastrointestinal tract infections: Cholera, traveler's diarrhea, shigella dysentery, acute intestinal amebiasis
- Chlamydial infections: Lympho-granuloma venereum, psittacosis, trachoma
- Sexually transmitted diseases: Non gonococcal urethritis, acute pelvic inflammatory disease, uncomplicated urethral and endocervical or rectal infections, gonorrhoea, syphilis, pyelonephritis, cystitis
- Other infections: Impetigo, furunculosis, inclusion conjunctivitis, brucellosis, tularemia, cellulitis, acne and Q-fever
Description
Highly active broad-spectrum antibiotic of tetracycline group effective against a wide range of Gram-positive and Gram-negative bacteria, spirochete, mycoplasma, rickettsia and mycobacteria
Pharmacology
Semisynthetic tetracycline antibiotic with broad spectrum activity, primarily bacteriostatic, active against Staphylococcus aureus, Nocardia, E. coli, Proteus mirabilis, Klebsiella, Haemophilus influenzae, H. ducreyi, Actinomyces, Brucella, Vibrio cholerae, Nocardia, Chlamydia, Mycoplasma, Rickettsiae, and certain spirochetes and Plasmodium falciparum
Dosage
- Usual dose: 200 mg on first day, then 100 mg daily for 7-10 days
- Severe infections: 200 mg daily for 10 days
- Acne: 100 mg daily
- Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days (14-21 days in pelvic inflammatory disease)
Administration
Capsules should be swallowed whole with plenty of fluid during meals while sitting or standing
Interaction
Absorption impaired by antacids, iron-containing preparations, bismuth salicylate, barbiturates, carbamazepine, phenytoin, and concurrent use with penicillin may render oral contraceptives less effective
Contraindications
Hypersensitivity to tetracyclines, children under 8 years of age, pregnant women, and lactating mothers
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Skin rashes
- Hemolytic anaemia
- Eosinophilia
Pregnancy & Lactation
Avoid in pregnant women and breastfeeding mothers due to the risk of staining and effects on bone growth in the fetus
Precautions & Warnings
Tetracycline drugs should not be used during tooth development (last half of pregnancy, infancy, and childhood up to 8 years) to prevent permanent discoloration of teeth
Therapeutic Class
Tetracycline group of drugs
Storage Conditions
Store in a cool, dry place protected from light and out of reach of children