Doxigen 100 mg (Capsule)
Unit Price: ৳ 2.15 (10 x 10: ৳ 214.80)
Strip Price: ৳ 21.48
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxycycline hydrochloride |
| Company | General pharmaceuticals ltd |
Indications
- Respiratory tract infections: Pneumonia, influenza, sinusitis, bronchitis, tonsillitis, tracheitis
- Gastrointestinal tract infections: Cholera, traveler's diarrhea, shigella dysentery, acute intestinal amebiasis
- Chlamydial infections: Lympho-granuloma venereum, psittacosis, trachoma
- Sexually transmitted diseases: Non-gonococcal urethritis, acute pelvic inflammatory disease, uncomplicated urethral and endocervical or rectal infections, gonorrhea, syphilis, pyelonephritis, cystitis
- Other infections: Impetigo, furunculosis, inclusion conjunctivitis, brucellosis, tularemia, cellulitis, acne and Q-fever
Description
- Highly active broad-spectrum antibiotic
- Effective against Gram-positive and Gram-negative bacteria, spirochete, mycoplasma, rickettsia, and mycobacteria
- Used as an alternate to penicillin in the treatment of gonorrhea and syphilis
- Main mechanism of action is on protein synthesis
Pharmacology
- Semisynthetic tetracycline antibiotic with broad-spectrum activity
- Primarily a bacteriostatic antibiotic
- More active against Staphylococcus aureus and Nocardia
- Active against penicillin-resistant strains of Staphylococcus aureus and certain Gram-negative strains of E. coli, Proteus mirabilis, and Klebsiella
- Active against Haemophilus influenzae, Actinomyces, Brucella, Vibrio cholerae, Nocardia, Chlamydia, Mycoplasma, Rickettsiae, and spirochetes such as Borellia recurrentis, Treponema pallidum, and Plasmodium falciparum
Dosage
- Usual dose: 200 mg on first day, then 100 mg daily for 7-10 days
- Severe infections (including refractory urinary tract infections): 200 mg daily for 10 days
- Acne: 100 mg daily
- Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days (14-21 days in pelvic inflammatory disease)
Administration
- Capsules should be swallowed whole with plenty of fluid during meals while sitting or standing
Interaction
- Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations
- Absorption of tetracyclines is also impaired by bismuth salicylate
- Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline
- Concurrent use of tetracyclines may render oral contraceptives less effective
- Patients on anticoagulant therapy may require downward adjustment of their anticoagulant dosages
- It is advisable to avoid giving tetracyclines in conjunction with penicillin
Contraindications
- Hypersensitivity to any tetracyclines
- Children under 8 years of age
- Pregnant women and lactating mothers
Side Effects
- Nausea, vomiting, diarrhea, skin rashes, hemolytic anemia, eosinophilia
Pregnancy & Lactation
- Should be avoided in pregnant women due to the risk of staining and effect on bone growth in the fetus
- Enter breast milk, thus mothers taking these drugs should not breastfeed their child
Precautions & Warnings
- The use of drugs of the tetracycline class during tooth development may cause permanent discoloration of teeth
Therapeutic Class
- Tetracycline group of drugs
Storage Conditions
- Keep all medicines out of reach of children
- Store in a cool and dry place, protected from light