Gentasol 80 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 10.95 (2 x 5: ৳ 109.48)

Medicine Details

Category Details
Generic Gentamicin sulfate injection
Company Techno drugs ltd

Indications

  • Treatment of serious infections caused by susceptible strains of microorganisms
  • Treatment of conditions including septicaemia, meningitis, respiratory tract infections, infected wounds, skin and skin structure infection, bone and soft tissue infections, urinary tract infections

Pharmacology

  • Proven bactericidal antibiotic
  • Active against broad spectrum of Gram-negative pathogens
  • Active against some Gram-positive organisms
  • Interferes with bacterial protein synthesis
  • Binds primarily to the 30S sub-units of bacterial ribosomes
  • Cell death results
  • Other mechanisms of action may contribute to bactericidal effect

Dosage & Administration

  • Given by intramuscular route
  • Can be given intravenously if required
  • Usual dose for adults is 3-5 mg/kg/day in three divided doses for 7 to 10 days
  • Dosing interval adjustment for impaired renal function
  • Pediatric dosing based on age
  • Intravenous administration requires dilution with sterile normal saline or 5% glucose in water
  • Infusion periods of 30 minutes to 2 hours recommended
  • Should be discarded following a single use

Interaction

  • Avoid concurrent use with other potentially nephrotoxic or ototoxic drugs
  • Potent diuretics may potentiate ototoxic effects
  • Inactivated by solutions containing beta-lactam antibiotics
  • Should not be administered simultaneously with penicillins & cephalosporins

Side Effects

  • Vestibular damage
  • Reversible nephrotoxicity
  • Auditory ototoxicity
  • Symptoms include dizziness, vertigo, tinnitus, roaring in the ears, hearing loss
  • Adverse renal effects more frequent in patients with history of renal impairment and larger than recommended doses

Pregnancy & Lactation

  • Safety not established for use in pregnancy and lactation
  • Crosses the placenta
  • Risk of ototoxicity in the fetus
  • Use only if seriousness of mother's condition justifies the risk
  • Small amounts detected in breast milk
  • Breastfeeding recommended to be discontinued during therapy unless benefits outweigh potential risk

Therapeutic Class

  • Aminoglycosides

Storage Conditions

  • Cool and dry place

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