Lopin Plus 5 mg+25 mg (Tablet)
Unit Price: ৳ 4.50 (30's pack: ৳ 135.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate atenolol |
| Company | Edruc limited |
Title
- Amlodipine and Atenolol 5/25 mg Tablet
Categories
- Medicine
- Pharmaceutical
- Cardiovascular
Description
- This medicine is indicated for patients with essential hypertension, patients with angina pectoris and hypertension as co-existing diseases, post myocardial infarction patients, and patients with refractory angina pectoris where nitrate therapy has failed. It is a fixed-dose combination of Amlodipine and Atenolol, known for its peripheral vasodilator and cardioselective beta-blocker effects. The recommended dosage is 5/25 mg tablet once daily, which may be increased as advised by physicians. It has interactions with drugs like Disopyramide, Ampicillin, oral antidiabetics, and insulin. Contraindications include hypersensitivity to either component, sinus bradycardia, heart block, cardiogenic shock, hypotension, congestive heart failure, and poor left ventricular function. Overall, it is well tolerated and has side effects such as fatigue, headache, edema, nausea, drowsiness, anxiety, and depression.
Indications
- Essential hypertension
- Angina pectoris
- Post myocardial infarction
- Refractory angina pectoris
Pharmacology
- Dihydropyridine calcium antagonist
- Peripheral vasodilator
- Cardioselective beta-blocker
- Inhibits transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle
- Reduces peripheral vascular resistance
- Reduces blood pressure
- Reduces coronary vasoreactivity
- Lowers cardiac demand by reducing afterload
- Reduces tone
- Decreases coronary vasoreactivity
- Lowers cardiac output
- Decreases plasma renin activity
- Reduces sympathetic outflow from CNS
- Reduces myocardial oxygen demand
Dosage and administration
- Recommended dosage is 5/25 mg tablet once daily
- Dosage may be increased to 5/25 mg two tablets daily or as advised by physicians
- Dosage should be individualized
Interactions
- Disopyramide
- Ampicillin
- Oral antidiabetics
- Insulin
Contraindications
- Hypersensitivity to either component
- Sinus bradycardia
- Heart block
- Cardiogenic shock
- Hypotension
- Congestive heart failure
- Poor left ventricular function
Side effects
- Fatigue
- Headache
- Edema
- Nausea
- Drowsiness
- Anxiety
- Depression
Pregnancy and lactation
- Use during pregnancy if expected benefit outweighs potential fetal risk
- Not recommended for nursing mothers
- Breast-feeding should be stopped if use is considered necessary
Precautions and warnings
- Use with caution in patients with airway obstruction
- Can be used in patients with renal impairment
- Caution in patients with severe liver damage
- Caution in drug withdrawal
Overdose effects
- Hypotension
- Congestive cardiac failure
- Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal
- Symptomatic treatment
Therapeutic class
- Combined antihypertensive preparations
Storage conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children