Genmax 0.3% (Ophthalmic Solution)

10 ml drop: ৳ 31.37

Medicine Details

Category Details
Generic Gentamicin sulfate ophthalmic
Company Osl pharma limited
Also available as
Genmax 03 eye ointment

Indications

  • Blepharitis
  • Blepharoconjunctivitis
  • Conjunctivitis
  • Dacryocystitis
  • Keratitis
  • Keratoconjunctivitis
  • Acute Meibomianitis
  • Corneal Ulcers
  • Otorrhea
  • External Otitis
  • Suppurative Otitis Media
  • Chronic Suppurative Otitis Media
  • Subacute Purulent Otitis Media
  • Postoperative Otorrhea

Pharmacology

  • Actively transported across bacterial cell membrane
  • Binds to specific receptor protein on the 30S subunit of bacterial ribosomes
  • Interferes with initiation complex between mRNA and the 30S subunit
  • Inhibits protein synthesis
  • DNA misreading leading to nonfunctional proteins
  • Polyribosomes splitting and inability to synthesize protein
  • Absorption following topical application to the eye
  • Active against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Niesseria gonorrhoea, Pseudomonus aeruginosa, Serratia marcescens

Dosage & Administration

  • 1-2 drops instilled in affected eye up to 6 times a day
  • More frequent instillation for severe infections
  • 2-3 drops instilled in affected ear every 3-4 times a day
  • Nighttime instillation
  • More frequent instillation for severe infections

Interaction

  • None reported with topical and Eye/Ear drops

Contraindications

  • History of sensitivity reaction to any components
  • Potential overgrowth of nonsusceptible organisms, including fungi

Side Effects

  • Irritation (erythema and pruritus) in dermatoses
  • Itching, redness, swelling
  • Ocular burning and irritation
  • Non-specific conjunctivitis
  • Conjunctival epithelial defects
  • Conjunctival hyperemia
  • Bacterial and corneal ulcer development

Pregnancy & Lactation

  • Possibility of foetal ototoxicity
  • Safety profile not yet established
  • Use only when considered essential

Precautions & Warnings

  • Discontinue if irritation or sensitization develops
  • Not for injection
  • Avoid subconjunctival injections
  • Avoid direct introduction into the anterior chamber of the eye

Therapeutic Class

  • Ophthalmic antibacterial drugs

Storage Conditions

  • Keep below 30°C
  • Away from light & moisture
  • Keep out of the reach of children
  • Avoid touching the container tip to the eye, eyelid, or any surface

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