Genmax 0.3% (Ophthalmic Ointment)

Indications

• Blepharitis
• Blepharoconjunctivitis
• Conjunctivitis
• Dacryocystitis
• Keratitis
• Keratoconjunctivitis
• Acute meibomianitis
• Corneal ulcers

Pharmacology

• Actively transported across bacterial cell membrane
• Binds to specific receptor protein on the 30S subunit of bacterial ribosomes
• Interferes with initiation complex between mRNA and the 30S subunit
• Inhibits protein synthesis
• May be absorbed following topical application to the eye
• Active against various microorganisms such as Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa

Dosage & Administration

• 1-2 drops instilled in affected eye up to 6 times a day
• Severe infections may require 1-2 drops every 15-20 minutes initially
• 2-3 drops should be instilled in the ear every 3-4 times a day and at night

Interaction

• None reported with topical and Eye/Ear drops

Contraindications

• Contraindicated in individuals with history of sensitivity reaction to any of its components
• May allow overgrowth of nonsusceptible organisms including fungi

Side Effects

• Irritation (erythema and pruritus)
• Itching, redness, swelling or other signs of irritation
• Ocular burning and irritation upon drug instillation
• Non-specific conjunctivitis
• Conjunctival epithelial defects
• Conjunctival hyperemia

Pregnancy & Lactation

• Possibility of fetal ototoxicity when applied topically to large denuded areas of skin
• Safety profile in pregnancy not yet established

Precautions & Warnings

• Discontinue if irritation or sensitization develops
• Not for injection, not for subconjunctival or direct introduction into the anterior chamber of the eye

Therapeutic Class

• Ophthalmic antibacterial drugs

Storage Conditions

• Keep below 30°C temperature
• Away from light & moisture
• Keep out of the reach of children
• Do not touch the tip of the container to the eye, eyelid or any surface

Related Brands

• Genmax 0.3% (Ophthalmic Solution) - osl-pharma-limited