Genacyn 0.3% (Ophthalmic Solution)
10 ml drop: ৳ 32.12
Medicine Details
| Category | Details |
|---|---|
| Generic | Gentamicin sulfate ophthalmic |
| Company | Square pharmaceuticals plc |
Indications
- Blepharitis
- Blepharoconjunctivitis
- Conjunctivitis
- Dacryocystitis
- Keratitis
- Keratoconjunctivitis
- Acute meibomianitis
- Corneal ulcers
- Otorrhea associated with external otitis
- Chronic suppurative otitis media
- Subacute purulent otitis media
- Postoperative otorrhea
Pharmacology
- Active transportation across bacterial cell membrane
- Binds to specific receptor protein on the 30S subunit of bacterial ribosomes
- Interferes with initiation complex between mRNA and the 30 S subunit
- Inhibits protein synthesis
- DNA misreading
- Nonfunctional proteins production
- Polyribosomes splitting
- Absorption through topical application to the eye
- Absorption through topical application to the ear
- Activity against Staphylococcus aureus
- Activity against Staphylococcus epidermidis
- Activity against Streptococcus pyogenes
- Activity against Streptococcus pneumoniae
- Activity against Escherichia coli
- Activity against Haemophilus influenzae
- Activity against Klebsiella pneumoniae
- Activity against Neisseria gonorrhoea
- Activity against Pseudomonas aeruginosa
- Activity against Serratia marcescens
Dosage & Administration
- 1-2 drops instilled in affected eye up to 6 times a day
- More frequent instillation for severe infections
- Area cleaning before ear drop instillation
- 2-3 drops instilled in the ear every 3-4 times a day
- Night-time instillation
- More frequent ear drop instillation if required
Interaction
- No reported interactions with topical and Eye/Ear drops
Contraindications
- History of sensitivity reaction to any components
- Potential overgrowth of nonsusceptible organisms, including fungi
Side Effects
- Irritation (erythema and pruritus) with dermatoses
- Itching
- Redness
- Swelling
- Ocular burning
- Irritation upon drug instillation
- Non-specific conjunctivitis
- Conjunctival epithelial defects
- Conjunctival hyperemia
- Development of bacterial and corneal ulcers
Pregnancy & Lactation
- Possible foetal ototoxicity
- Safety profile not established
- Administration when essential
Precautions & Warnings
- Discontinue treatment if irritation or sensitization develops
- Not for injection
- Avoid subconjunctival injection
- Avoid direct introduction into the anterior chamber of the eye
Therapeutic Class
- Ophthalmic antibacterial drugs
Storage Conditions
- Keep below 30°C
- Keep away from light & moisture
- Keep out of the reach of children
- Avoid contamination by not touching the tip to the eye or any surface