Acryth 125 mg/5 ml (Powder for Suspension)

Indications

• Upper respiratory tract infections
• Lower respiratory tract infections
• Ear infections
• Eye infections
• Skin and Soft tissue infections
• Gastrointestinal tract infections
• Prophylaxis
• Other infections

Description

• Belongs to the macrolides group of antibiotics
• Bacteriostatic or bactericidal action based on interference with ribosomal protein synthesis in bacterial cell
• Used for treating infections caused by penicillinase producing staphylococci
• Susceptible micro-organisms include Gram (+)ve, Gram (-)ve, Mycoplasma pneumoniae, Legionella pneumophila, Bacteroides fragilis, B.oralis, B.melaninogenicus, Fusobacterium, Chlamydia trachomatis, Treponema pallidum

Pharmacology

• Inhibits microsomal protein synthesis in susceptible organisms
• Specific binding to the 50S subunit or 70S ribosome occurs
• Active against many Grampositive bacteria, some Gram-negative bacteria, mycoplasmas, and chlamydia
• Absorption is diminished by presence of food
• Significant distribution throughout body tissue and fluids, including cerebrospinal fluid
• Excretion primarily occurs in the urine and bile

Dosage & Administration

• Adults and Children over 8 years: 250-500 mg every six hours for mild to moderate infections
• Elderly: no special dosage recommendation
• Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day
• Infants and Children upto 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses

Interaction

• Use with theophylline may increase serum theophylline levels and potential theophylline toxicity

Contraindications

• Known hypersensitivity to Erythromycin

Side Effects

• Rare allergic reactions
• Occasional abdominal discomfort, nausea, vomiting

Pregnancy & Lactation

• No evidence of human teratogenicity or toxicity
• Caution advised for pregnant patients and lactating mothers due to placental barrier crossing and excretion in breast milk

Precautions & Warnings

• Given with care in patients with impaired hepatic function

Overdose Effects

• Discontinue in case of overdosage
• Prompt elimination of unabsorbed drug should be priority
• Not removed by peritoneal dialysis or haemodialysis

Therapeutic Class

• Anti-diarrhoeal Antimicrobial drugs
• Macrolides

Reconstitution

• Direction for reconstitution of suspension provided
• Shake well before each use
• Store reconstituted suspension in a cool, dry place and discard after 7 days

Storage Conditions

• Store below 25°C temperature, away from light & moisture
• Keep out of the reach of children

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