A-Mycin 250 mg/5 ml (Powder for Suspension)
Medicine Details
| Category | Details |
|---|---|
| Generic | Erythromycin oral |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Upper respiratory tract infections: Tonsilitis, Peritonsillar abscess, Pharyngitis, laryngitis, Sinusitis
- Lower respiratory tract infections: Tracheitis, acute and chronic bronchitis
- Ear infections: Otitis media, otitis externa, mastoiditis
- Eye infections: Blepharitis, established trachoma
- Skin and Soft tissue infections: Boils and carbuncles, impetigo, abscesses, pustular acne, paromychia, cellulitis, erysipelas
- Gastrointestinal tract infections: Cholecystitis, staphylococcal enterocolitis
- Prophylaxis: Pre and post-operative, trauma, burns, rheumatic fever
- Other infections: Osteomyelitis, diptheria, scarlet fever, whooping cough
Description
A-Mycin belongs to the macrolides group of antibiotics. It exerts a bacteriostatic or bactericidal action based on specific interference with ribosomal protein synthesis within the bacterial cell. THROCIN is mainly used for the treatment of infections caused by penicillinase producing staphylococci. The following micro-organisms are particularly susceptible to A-Mycin. Gram (+)ve : Cocci and bacilli. Gram (-)ve : Neisseria catarhalis, N.meningitis, N.gonorrhoea, Haemophilus influenzae, Brodetella, H. pertussis.Other micro-organisms : Mycoplasma pneumoniae, Legionella pneumophila, Bacteroides fragilis, B.oralis, B.melaninogenicus, Fusobacterium, Chlamydia trachomatis, Treponema pallidum
Pharmacology
- Inhibits microsomal protein synthesis in susceptible organisms by inhibiting the translocation process
- Active against many Grampositive bacteria and some Gram-negative bacteria
- Active against mycoplasmas and chlamydia
- Specific binding to the 50S subunit or 70S ribosome occurs in susceptible organisms
Dosage & Administration
- Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections. This may be increased upto 4 gm. or more daily in severe cases
- Elderly: No special dosage recommendation
- Children aged 2 to 8 years: 250 mg. every six hours or 30-50 mg/kg body weight per day divided into four equal dosage
- Infants and Children upto 2 years: 500 mg. in divided doses or 30-50 mg/kg body weight in divided doses
Interaction
Use in patients receiving high dosage of theophylline may be associated with an increase of serum theophylline levels and potential theophylline toxicity. In such cases the dose of theophylline should be reduced
Contraindications
Known hypersensitivity to Erythromycin
Side Effects
- Allergic reactions are rare and mild
- Anaphylaxis has occurred
- Occasional abdominal discomfort after oral administration
- Sometimes associated with nausea and vomiting
Pregnancy & Lactation
Clinical and Laboratory studies have shown no evidence in human of teratogenicity or toxicity. Caution should be exercised when prescribing to pregnant patients and lactating mothers
Precautions & Warnings
Should be given with care in patients with impaired hepatic function, as it is excreted principally in the bile
Overdose Effects
Overdosage should be discontinued. Prompt elimination of unabsorbed drug and all other appropriate measures should be instituted. A-Mycin is not removed by peritoneal dialysis or haemodialysis
Therapeutic Class
Anti-diarrhoeal Antimicrobial drugs, Macrolides
Reconstitution
Shake the bottle to loosen powder. Add 60 ml or 100 ml of boiled and cooled water to the dry powder of the bottle. For ease of preparation, add water to the bottle in two proportions. Shake well after each addition until all the powder is in suspension. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 7 days
Storage Conditions
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children