A-Mycin 200 mg/5 ml (Pediatric Drops)
60 ml drop: ৳ 60.00
Medicine Details
Category | Details |
---|---|
Generic | Erythromycin oral |
Company | Aristopharma ltd |
Also available as |
Indications
- Upper respiratory tract infections: Tonsilitis, Peritonsillar abscess, Pharyngitis, Laryngitis, Sinusitis
- Lower respiratory tract infections: Tracheitis, Acute and chronic bronchitis
- Ear infections: Otitis media, Otitis externa, Mastoiditis
- Eye infections: Blepharitis, Established trachoma
- Skin and Soft tissue infections: Boils and carbuncles, Impetigo, Abscesses, Pustular acne, Paromychia, Cellulitis, Erysipelas
- Gastrointestinal tract infections: Cholecystitis, Staphylococcal enterocolitis
- Prophylaxis: Pre and post-operative, Trauma, Burns, Rheumatic fever
- Other infections: Osteomyelitis, Dipheria, Scarlet fever, Whooping cough
Description
- Belongs to the macrolides group of antibiotics
- Exerts bacteriostatic or bactericidal action based on specific interference with ribosomal protein synthesis within the bacterial cell
- Mainly used for the treatment of infections caused by penicillinase producing staphylococci
- Particularly susceptible to Gram (+)ve cocci and bacilli, Gram (-)ve Neisseria catarhalis, N.meningitis, N.gonorrhoea, Haemophilus influenzae, Brodetella, H. pertussis, Mycoplasma pneumoniae, Legionella pneumophila, Bacteroides fragilis, B.oralis, B.melaninogenicus, Fusobacterium, Chlamydia trachomatis, Treponema pallidum
Pharmacology
- Inhibits microsomal protein synthesis in susceptible organisms
- Active against many Grampositive bacteria, some Gram-negative bacteria, mycoplasmas, and chlamydia
- Destroyed by acid and is therefore administered in the form of stable ester
- Widely distributed throughout body tissue and fluids with some retention in the liver and spleen
- Enters the cerebrospinal fluid when the meninges are inflamed
- Crosses the placenta and is excreted in the milk
Dosage & Administration
- Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections. This may be increased upto 4 gm. or more daily in severe cases
- Elderly: Erythromycin may be administered if desired three times daily or twice daily by giving one-third or half of the total daily requirement 8 hourly or 12 hourly respectively
- Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day divided into four equal dosages
- Infants and Children upto 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses
Interaction
- Associated with an increase of serum theophylline levels and potential theophylline toxicity in patients receiving high dosage of theophylline
Contraindications
- Known hypersensitivity to Erythromycin
Side Effects
- Rare and mild allergic reactions, although anaphylaxis has occurred
- Occasional abdominal discomfort after oral administration, with nausea and vomiting
Pregnancy & Lactation
- No evidence in human of teratogenicity or toxicity
- Caution should be exercised when prescribing this drug to pregnant patients and lactating mothers
Precautions & Warnings
- Given with care in patients with impaired hepatic function
Overdose Effects
- A-Mycin should be discontinued in case of overdosage
- Prompt elimination of unabsorbed drug and all other appropriate measures should be instituted
- Not removed by peritoneal dialysis or haemodialysis
Therapeutic Class
- Anti-diarrhoeal Antimicrobial drugs, Macrolides
Reconstitution
- Shake the bottle to loosen powder
- Add 60 ml or 100 ml of boiled and cooled water to the dry powder of the bottle
- Shake the suspension well before each use
- Store the reconstituted suspension in a cool and dry place, preferably in refrigerator, and discard the unused portion after 7 days
Storage Conditions
- Keep below 25°C temperature, away from light & moisture, and out of the reach of children
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