A-Mycin 200 mg/5 ml (Pediatric Drops)

60 ml drop: ৳ 60.00

Medicine Details

Indications

  • Upper respiratory tract infections: Tonsilitis, Peritonsillar abscess, Pharyngitis, Laryngitis, Sinusitis
  • Lower respiratory tract infections: Tracheitis, Acute and chronic bronchitis
  • Ear infections: Otitis media, Otitis externa, Mastoiditis
  • Eye infections: Blepharitis, Established trachoma
  • Skin and Soft tissue infections: Boils and carbuncles, Impetigo, Abscesses, Pustular acne, Paromychia, Cellulitis, Erysipelas
  • Gastrointestinal tract infections: Cholecystitis, Staphylococcal enterocolitis
  • Prophylaxis: Pre and post-operative, Trauma, Burns, Rheumatic fever
  • Other infections: Osteomyelitis, Dipheria, Scarlet fever, Whooping cough

Description

  • Belongs to the macrolides group of antibiotics
  • Exerts bacteriostatic or bactericidal action based on specific interference with ribosomal protein synthesis within the bacterial cell
  • Mainly used for the treatment of infections caused by penicillinase producing staphylococci
  • Particularly susceptible to Gram (+)ve cocci and bacilli, Gram (-)ve Neisseria catarhalis, N.meningitis, N.gonorrhoea, Haemophilus influenzae, Brodetella, H. pertussis, Mycoplasma pneumoniae, Legionella pneumophila, Bacteroides fragilis, B.oralis, B.melaninogenicus, Fusobacterium, Chlamydia trachomatis, Treponema pallidum

Pharmacology

  • Inhibits microsomal protein synthesis in susceptible organisms
  • Active against many Grampositive bacteria, some Gram-negative bacteria, mycoplasmas, and chlamydia
  • Destroyed by acid and is therefore administered in the form of stable ester
  • Widely distributed throughout body tissue and fluids with some retention in the liver and spleen
  • Enters the cerebrospinal fluid when the meninges are inflamed
  • Crosses the placenta and is excreted in the milk

Dosage & Administration

  • Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections. This may be increased upto 4 gm. or more daily in severe cases
  • Elderly: Erythromycin may be administered if desired three times daily or twice daily by giving one-third or half of the total daily requirement 8 hourly or 12 hourly respectively
  • Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day divided into four equal dosages
  • Infants and Children upto 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses

Interaction

  • Associated with an increase of serum theophylline levels and potential theophylline toxicity in patients receiving high dosage of theophylline

Contraindications

  • Known hypersensitivity to Erythromycin

Side Effects

  • Rare and mild allergic reactions, although anaphylaxis has occurred
  • Occasional abdominal discomfort after oral administration, with nausea and vomiting

Pregnancy & Lactation

  • No evidence in human of teratogenicity or toxicity
  • Caution should be exercised when prescribing this drug to pregnant patients and lactating mothers

Precautions & Warnings

  • Given with care in patients with impaired hepatic function

Overdose Effects

  • A-Mycin should be discontinued in case of overdosage
  • Prompt elimination of unabsorbed drug and all other appropriate measures should be instituted
  • Not removed by peritoneal dialysis or haemodialysis

Therapeutic Class

  • Anti-diarrhoeal Antimicrobial drugs, Macrolides

Reconstitution

  • Shake the bottle to loosen powder
  • Add 60 ml or 100 ml of boiled and cooled water to the dry powder of the bottle
  • Shake the suspension well before each use
  • Store the reconstituted suspension in a cool and dry place, preferably in refrigerator, and discard the unused portion after 7 days

Storage Conditions

  • Keep below 25°C temperature, away from light & moisture, and out of the reach of children

Related Brands