Arigram 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 60.00

Medicine Details

Category Details
Generic Erythromycin oral
Company Central pharmaceuticals ltd

Title

  • Arigram 500mg Tablet

Categories

  • Medicine
  • Antibiotic
  • Macrolide

Description

Arigram belongs to the macrolides group of antibiotics. It exerts a bacteriostatic or bactericidal action based on specific interference with ribosomal protein synthesis within the bacterial cell.

Indications

  • Treatment of upper respiratory tract infections like tonsillitis, sinusitis
  • Treatment of lower respiratory tract infections like bronchitis
  • Treatment of ear, eye, skin, soft tissue, gastrointestinal tract infections
  • Prophylaxis for pre and post-operative, trauma, burns, rheumatic fever
  • Treatment of osteomyelitis, diphtheria, scarlet fever, whooping cough

Pharmacology

  • Mode of Action: Inhibits microsomal protein synthesis in susceptible organisms
  • Active Against:
    • Gram-positive bacteria
    • Some Gram-negative bacteria
    • Mycoplasmas
    • Chlamydia
  • Absorption: Base destroyed by acid, administered in stable ester form
  • Blood Concentration: Peak serum concentrations attained in 1 to 4 hours
  • Distribution: Widely distributed throughout body tissue and fluids
  • Excretion: 5 to 15% excreted in urine, large amounts excreted in bile

Dosage & Administration

  • Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections
  • Elderly: No special dosage recommendation
  • Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day
  • Infants and Children up to 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses

Interaction

Use with high dosage of theophylline may increase serum theophylline levels

Contraindications

Known hypersensitivity to Erythromycin

Side Effects

  • Rare allergic reactions
  • Occasional abdominal discomfort after oral administration
  • Nausea and vomiting

Pregnancy & Lactation

Caution should be exercised when prescribing to pregnant patients and lactating mothers

Precautions & Warnings

Given with care in patients with impaired hepatic function

Overdose Effects

Discontinue upon overdosage, handling with prompt elimination of unabsorbed drug

Therapeutic Class

  • Anti-diarrhoeal
  • Antimicrobial drugs
  • Macrolides

Reconstitution

Direction for reconstitution of suspension provided

Storage Conditions

Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.

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