Tenocab 5 mg+25 mg (Tablet)

Unit Price: ৳ 6.00 (10 x 10: ৳ 600.00)

Strip Price: ৳ 60.00

Medicine Details

Category	Details
Generic	Amlodipine besilate atenolol
Company	Aci limited
Also available as	Tenocab 5 mg tablet

Indications

Patients with essential hypertension
Patients with angina pectoris & hypertension as co-existing diseases
In post Ml patients
In patients with refractory angina pectoris where nitrate therapy has failed

Pharmacology

Amlodipine is a dihydropyridine calcium antagonist
It inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle
It has a greater effect on vascular smooth muscle than on cardiac muscle
Amlodipine reduces tone, decreases coronary vasoreactivity and lowers cardiac demand by reducing afterload
Atenolol is a cardioselective beta-blocker
Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS
Atenolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects

Dosage & Administration

The recommended dosage is Amlodipine and Atenolol 5/25 mg tablet once daily. If necessary, the dosage may be increased to 5/25 mg two tablets daily or as advised by the physicians. The dosage however should be individualized

Interaction

Disopyramide reduces the clearance of disopyramide by 20%
Additive negative inotropic effects on the heart may be produced
Ampicillin at doses of 1 gm and above may reduce Atenolol levels
Oral antidiabetics and insulin: Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion e.g. in response to oral antidiabetics
Atenolol has less potential for these actions

Contraindications

Hypersensitivity to either component
Sinus bradycardia
Second and higher degrees of heart block
Cardiogenic shock
Hypotension
Congestive heart failure
Poor left ventricular function

Side Effects

fatigue
headache
edema
nausea
drowsiness
anxiety
depression

Pregnancy & Lactation

The combination should be used during pregnancy only if the expected benefit outweighs the potential fetal risk. The combination should not be used by nursing mothers. If its use is considered necessary, breast-feeding should be stopped

Precautions & Warnings

The combination should be used with caution in patients with airway obstruction
The combination can be used in patients with renal impairment
Caution may be necessary in the use of the combination in patients with severe liver damage because of prolongation of the elimination half-life of Amlodipine
Since coronary heart disease may exist without being recognized, patients should be warned against stopping the drug suddenly
Any discontinuation should be gradual and under observation

Overdose Effects

Though not documented, hypotension and less frequently congestive cardiac failure may occur in cases of overdosage. Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal. Symptomatic treatment is suggested

Therapeutic Class

Combined antihypertensive preparations

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children