Erom 500 mg (Tablet)

Unit Price: ৳ 8.63 (50's pack: ৳ 431.50)

Medicine Details

Category Details
Generic Erythromycin oral
Company Kemiko pharmaceuticals ltd
Also available as
Erom 250 mg tablet Erom 125 mg suspension

Title

  • Erom - Antibiotic Tablet

Categories

  • Medicine
  • Health & Wellness
  • Pharmaceuticals

Description

  • Highly effective in treating a wide variety of clinical infections caused by susceptible micro-organisms

Indications

  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Ear infections
  • Eye infections
  • Skin and Soft tissue infections
  • Gastrointestinal tract infections
  • Prophylaxis
  • Other infections

Active Ingredients

  • Erythromycin

Therapeutic Class

  • Anti-diarrhoeal Antimicrobial drugs
  • Macrolides

Mode of Action

  • Inhibits microsomal protein synthesis in susceptible organisms
  • Interferes with ribosomal protein synthesis within the bacterial cell
  • Bacteriostatic or bactericidal action

Micro-organisms Susceptible to Erom

  • Gram (+)ve Cocci and bacilli
  • Gram (-)ve Neisseria catarhalis, N.meningitis, N.gonorrhoea, Haemophilus influenzae, Brodetella, H. pertussis
  • Mycoplasma pneumoniae
  • Legionella pneumophila
  • Bacteroides fragilis, B.oralis, B.melaninogenicus
  • Fusobacterium
  • Chlamydia trachomatis
  • Treponema pallidum

Dosage & Administration

  • Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections
  • Elderly: No special dosage recommendation
  • Children aged 2 to 8 years: 250 mg. every six hours or 30-50 mg/kg body weight per day
  • Infants and Children upto 2 years: 500 mg. in divided doses or 30-50 mg/kg body weight in divided doses

Interaction

  • Potential interaction with high dosage of theophylline leading to increased serum theophylline levels and potential theophylline toxicity

Contraindications

  • Known hypersensitivity to Erythromycin

Side Effects

  • Rare allergic reactions
  • Mild abdominal discomfort
  • Nausea and vomiting

Pregnancy & Lactation

  • Caution advised during pregnancy and lactation due to potential placental barrier crossing and excretion in breast milk

Precautions & Warnings

  • Given with care in patients with impaired hepatic function

Overdose Effects

  • Discontinue in case of overdosage
  • Prompt elimination of unabsorbed drug
  • Not removed by peritoneal dialysis or haemodialysis

Reconstitution

  • Direction for reconstitution of suspension
  • Shake well before use
  • Store in a cool and dry place, preferably in refrigerator
  • Unused portion should be discarded after 7 days

Storage Conditions

  • Keep below 25°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

Pharmacology

  • Specific binding to the 50S subunit or 70S ribosome in susceptible organisms
  • Active against many Gram-positive bacteria and some Gram-negative bacteria
  • Widely distributed throughout body tissue and fluids
  • Enters cerebrospinal fluid when meninges are inflamed
  • Crosses the placenta and is excreted in the milk

Absorption

  • Erythromycin base is destroyed by acid and is therefore administered in the form of stable ester
  • Diminished absorption rates in the presence of food

Blood Concentration

  • Peak serum concentrations attained in 1 to 4 hours
  • Serum half-life is 1.2 to 4 hours

Distribution

  • Widely distributed throughout body tissue and fluids
  • Some retention in the liver and spleen
  • Protein binding of erythromycin base is 73%

Excretion

  • 5 to 15 % of the dose of erythromycin is excreted in the urine
  • Large amounts of the unchanged active substance are excreted in the bile

Related Brands