Eromycin DS 500 mg (Tablet)

Unit Price: ৳ 10.35 (5 x 6: ৳ 310.50)
Strip Price: ৳ 62.10

Medicine Details

Product Title

  • Eromycin DS

Category

  • Antimicrobial drugs
  • Macrolides
  • Antibiotics

Description

  • Belongs to the macrolides group of antibiotics
  • Exerts bacteriostatic or bactericidal action based on specific interference with ribosomal protein synthesis within the bacterial cell
  • Used for the treatment of infections caused by penicillinase producing staphylococci
  • Effective against a wide variety of clinical infections

Indications

  • Treatment of upper respiratory tract infections like tonsillitis, sinusitis, and pharyngitis
  • Effective against lower respiratory tract infections such as acute and chronic bronchitis
  • Treatment of ear infections like otitis media and otitis externa
  • Used for eye infections including blepharitis
  • Effective against skin and soft tissue infections such as boils, impetigo, and cellulitis
  • Treatment of gastrointestinal tract infections like staphylococcal enterocolitis
  • Used for prophylaxis in pre and post-operative, trauma, burns, and rheumatic fever
  • Effective against other infections like osteomyelitis, diphtheria, and scarlet fever

Mode of Action

  • Inhibits microsomal protein synthesis in susceptible organisms
  • Binds to the 50S subunit or 70S ribosome in bacteria
  • Active against many Gram-positive and some Gram-negative bacteria
  • Active against mycoplasmas and chlamydia

Dosage & Administration

  • Adults and children over 8 years: 250-500 mg every six hours for mild to moderate infections
  • Elderly: No special dosage recommendation
  • Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day
  • Infants and children up to 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses

Interaction

  • Use in patients receiving high dosage of theophylline may be associated with an increase of serum theophylline levels and potential theophylline toxicity

Contraindications

  • Known hypersensitivity to Erythromycin

Side Effects

  • Rare allergic reactions with mild instances of anaphylaxis
  • Occasional abdominal discomfort after oral administration, sometimes with nausea and vomiting

Pregnancy & Lactation

  • No evidence of teratogenicity or toxicity in human studies
  • Caution advised when prescribing to pregnant patients and lactating mothers

Precautions & Warnings

  • Given with care in patients with impaired hepatic function as it is excreted principally in the bile

Overdose Effects

  • Discontinue in case of overdosage
  • Prompt elimination of unabsorbed drug and instituting appropriate measures

Therapeutic Class

  • Anti-diarrheal Antimicrobial drugs
  • Macrolides

Reconstitution

  • Shake the bottle to loosen powder
  • Add boiled and cooled water to the dry powder of the bottle
  • Shake well after each addition until all the powder is in suspension
  • Keep the reconstituted suspension in a cool and dry place and discard the unused portion after 7 days

Storage Conditions

  • Keep below 25°C, away from light and moisture
  • Keep out of the reach of children

Pharmacology

  • Absorption: Erythromycin base is destroyed by acid and is therefore administered in the form of stable esters
  • Blood concentration: Peak serum concentrations of 0.9 to 1.4 mg/ml are attained in 1 to 4 hours after an oral dose of 500 mg
  • Distribution: Widely distributed throughout body tissue and fluids with some retention in the liver and spleen
  • Excretion: 5 to 15% of the dose of erythromycin is excreted in the urine and large amounts of the unchanged active substance are excreted in the bile

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