Eromycin 125 mg/5 ml (Powder for Suspension)
Medicine Details
| Category | Details |
|---|---|
| Generic | Erythromycin oral |
| Company | Square pharmaceuticals plc |
| Also available as |
Title
- Eromycin
Categories
- Antibiotic
- Medication
- Pharmaceutical
Description
Eromycin belongs to the macrolides group of antibiotics. It exerts a bacteriostatic or bactericidal action based on specific interference with ribosomal protein synthesis within the bacterial cell.
Indications
- Upper respiratory tract infections
- Lower respiratory tract infections
- Ear infections
- Eye infections
- Skin and Soft tissue infections
- Gastrointestinal tract infections
- Prophylaxis
- Other infections
Pharmacology
- Mode of Action: Inhibits microsomal protein synthesis in susceptible organisms by inhibiting the translocation process
- Susceptible Micro-organisms:
- Gram (+)ve : Cocci and bacilli
- Gram (-)ve : Neisseria catarhalis, N.meningitis, N.gonorrhoea, Haemophilus influenzae, Brodetella, H. pertussis
- Other micro-organisms : Mycoplasma pneumoniae, Legionella pneumophila, Bacteroides fragilis, B.oralis, B.melaninogenicus, Fusobacterium, Chlamydia trachomatis, Treponema pallidum
- Absorption: Erythromycin base is destroyed by acid and is therefore administered in the form of stable ester
- Blood Concentration: Peak serum concentrations of 0.9 to 1.4 or 0.4 to 1.8 mg/ml
- Distribution: Widely distributed throughout body tissue and fluids with some retention in the liver and spleen
- Excretion: 5 to 15% of the dose of erythromycin is excreted in the urine and large amounts of the unchanged active substance are excreted in the bile
Dosage & Administration
- Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections
- Elderly: No special dosage recommendation
- Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day divided into four equal dosage
- Infants and Children up to 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses
Interaction
Use in patients who are receiving high dosage of theophylline may be associated with an increase of serum theophylline levels and potential theophylline toxicity
Contraindications
Known hypersensitivity to Erythromycin
Side Effects
- Allergic reactions are rare and mild
- Abdominal discomfort after oral administration
- Nausea and vomiting
Pregnancy & Lactation
Caution should be exercised when prescribing this drug to pregnant patients and lactating mothers
Precautions & Warnings
Given with care in patients with impaired hepatic function
Overdose Effects
Should be discontinued. Overdosage should be handled with the prompt elimination of unabsorbed drug
Therapeutic Class
- Anti-diarrhoeal
- Antimicrobial drugs
- Macrolides
Reconstitution
Shake the bottle to loosen powder. Add water to the dry powder of the bottle. Shake well after each addition until all the powder is in suspension. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 7 days.
Storage Conditions
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children