Erosa 500 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Erythromycin oral |
| Company | Biopharma limited |
| Also available as |
Indications
- Upper respiratory tract infections: Tonsillitis, Peritonsillar abscess, Pharyngitis, Laryngitis, Sinusitis
- Lower respiratory tract infections: Tracheitis, Acute and chronic bronchitis
- Ear infections: Otitis media, Otitis externa, Mastoiditis
- Eye infections: Blepharitis, Trachoma
- Skin and soft tissue infections: Boils and carbuncles, Impetigo, Abscesses, Pustular acne, Paronychia, Cellulitis, Erysipelas
- Gastrointestinal tract infections: Cholecystitis, Staphylococcal enterocolitis
- Prophylaxis: Pre and post-operative, Trauma, Burns, Rheumatic fever
- Other infections: Osteomyelitis, Diphtheria, Scarlet fever, Whooping cough
Description
Belongs to the macrolides group of antibiotics. Exerts a bacteriostatic or bactericidal action based on specific interference with ribosomal protein synthesis within the bacterial cell.
Micro-organisms Susceptible
- Gram positive: Cocci and bacilli
- Gram negative: Neisseria catarhalis, N. meningitis, N. gonorrhoea, Haemophilus influenzae, Bordetella, H. pertussis
- Other micro-organisms: Mycoplasma pneumoniae, Legionella pneumophila, Bacteroides fragilis, B. oralis, B. melaninogenicus, Fusobacterium, Chlamydia trachomatis, Treponema pallidum
Mode of Action
Inhibits microsomal protein synthesis in susceptible organisms by inhibiting the translocation process. Specific binding to the 50S subunit or 70S ribosome occurs in these organisms.
Absorption
Base is destroyed by acid and is administered in the form of stable ester. Absorption rates are diminished by the presence of food.
Blood Concentration
Peak serum concentrations of 0.9 to 1.4 or 0.4 to 1.8 mg/ml. respectively are attained in 1 to 4 hours after an oral dose of 500 mg.
Distribution
Widely distributed throughout body tissue and fluids with some retention in the liver and spleen.
Excretion
5 to 15% of the dose is excreted in the urine and large amounts of the unchanged active substance are excreted in the bile.
Dosage & Administration
- Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections, may be increased up to 4 gm. or more daily in severe cases
- Elderly: No special dosage recommendation
- Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day divided into four equal dosages
- Infants and Children up to 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses
Interaction
Use in patients receiving high dosage of theophylline may be associated with an increase of serum theophylline levels and potential theophylline toxicity.
Contraindications
Known hypersensitivity to Erythromycin.
Side Effects
- Allergic reactions are rare and mild although anaphylaxis has occurred
- Occasional abdominal discomfort after oral administration, sometimes with nausea and vomiting
Pregnancy & Lactation
Caution should be exercised when prescribing this drug to pregnant patients and lactating mothers since erythromycin crosses the placental barrier and is excreted in breast milk.
Precautions & Warnings
Give with care in patients with impaired hepatic function.
Overdose Effects
Should be discontinued. Prompt elimination of unabsorbed drug and all other appropriate measures should be instituted.
Therapeutic Class
Anti-diarrhoeal Antimicrobial drugs, Macrolides
Reconstitution
Shake the bottle to loosen powder. Add boiled and cooled water to the dry powder. Shake well after each addition until all the powder is in suspension. Store in a cool and dry place, preferably in refrigerator and discard after 7 days.
Storage Conditions
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.