Erybac 250 mg (Tablet)

Unit Price: ৳ 4.50 (5 x 10: ৳ 225.00)

Strip Price: ৳ 45.00

Medicine Details

Category	Details
Generic	Erythromycin oral
Company	Drug international ltd
Also available as	Erybac 500 mg tablet Erybac 125 mg suspension

Indications

Upper respiratory tract infections
Lower respiratory tract infections
Ear infections
Eye infections
Skin and Soft tissue infections
Gastrointestinal tract infections
Prophylaxis
Osteomyelitis
Diptheria
Scarlet fever
Whooping cough

Description

belongs to the macrolides group of antibiotics, exerts bacteriostatic or bactericidal action, used for treatment of infections caused by penicillinase producing staphylococci, susceptible to various micro-organisms

Pharmacology

Mode of Action: Inhibits microsomal protein synthesis, specific binding to the 50S subunit or 70S ribosome, active against Grampositive bacteria, some Gram-negative bacteria, mycoplasmas, and chlamydia
Absorption: Destroyed by acid, stearate form diminishes absorption, delayed absorption in the presence of food
Blood Concentration: Peak serum concentrations, serum half-life, prolonged half-life in oliguria
Distribution: Widely distributed throughout body tissue and fluids, retention in the liver and spleen, protein binding, enters cerebrospinal fluid with inflamed meninges, crosses placenta, excreted in milk
Excretion: Percentage excreted in urine and bile, unchanged active substance excreted in bile

Dosage & Administration

Adult and Children over 8 years:
- 250-500 mg every six hours for mild to moderate infections
- Increased upto 4 gm daily in severe cases
Elderly: No special dosage recommendation, may be administered three times daily or twice daily by giving one-third or half of the total daily requirement 8 hourly or 12 hourly respectively
Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day divided into four equal dosage
Infants and Children upto 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses

Interaction

May increase serum theophylline levels and potential theophylline toxicity

Contraindications

Known hypersensitivity to Erythromycin

Side Effects

Allergic reactions rare and mild
Abdominal discomfort after oral administration, sometimes with nausea and vomiting

Pregnancy & Lactation

No evidence of human teratogenicity or toxicity, exercise caution when prescribing to pregnant patients and lactating mothers

Precautions & Warnings

Given with care in patients with impaired hepatic function

Overdose Effects

Prompt elimination of unabsorbed drug, not removed by peritoneal dialysis or haemodialysis

Therapeutic Class

Anti-diarrhoeal Antimicrobial drugs, Macrolides

Reconstitution

Directions for reconstitution of suspension, storage of reconstituted suspension

Storage Conditions

Keep below 25°C temperature, away from light and moisture, keep out of the reach of children