Erymex 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 84.50

Medicine Details

Category Details
Generic Erythromycin oral
Company Ibn sina pharmaceuticals ltd
Also available as
Erymex 500 mg tablet

Indications

  • Upper respiratory tract infections
  • Tonsilitis
  • Peritonsillar abscess
  • Pharyngitis
  • Laryngitis
  • Sinusitis
  • Lower respiratory tract infections
  • Tracheitis
  • Acute and chronic bronchitis
  • Ear infections
  • Otitis media
  • Otitis externa
  • Mastoiditis
  • Eye infections
  • Blepharitis
  • Established trachoma
  • Skin and Soft tissue infections
  • Boils and carbuncles
  • Impetigo
  • Abscesses
  • Pustular acne
  • Paronychia
  • Cellulitis
  • Erysipelas
  • Gastrointestinal tract infections
  • Cholecystitis
  • Staphylococcal enterocolitis
  • Prophylaxis
  • Pre and post-operative
  • Trauma
  • Burns
  • Rheumatic fever
  • Other infections
  • Osteomyelitis
  • Diptheria
  • Scarlet fever
  • Whooping cough

Description

  • Belongs to the macrolides group of antibiotics
  • Exerts a bacteriostatic or bactericidal action
  • Interferes with ribosomal protein synthesis
  • Effective against penicillinase producing staphylococci
  • Particularly susceptible to Erymex: Gram positive cocci and bacilli, Gram negative Neisseria, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, Bacteroides fragilis, Chlamydia trachomatis, Treponema pallidum

Pharmacology

  • Inhibits microsomal protein synthesis
  • Binds to 50S subunit or 70S ribosome in susceptible organisms
  • Active against Gram-positive, some Gram-negative bacteria, mycoplasmas, and chlamydia
  • Destroyed by acid; administered in the form of stable ester
  • Widely distributed throughout body tissue and fluids
  • Enters cerebrospinal fluid and crosses the placenta
  • Excreted in the milk and urine

Dosage & Administration

  • Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections
  • Elderly: No special dosage recommendation
  • Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day
  • Infants and Children upto 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses

Interaction

  • May increase serum theophylline levels
  • Associated with potential theophylline toxicity
  • Theophylline dosage should be reduced during co-administration

Contraindications

  • Known hypersensitivity to Erythromycin

Side Effects

  • Rare allergic reactions
  • Mild anaphylaxis
  • Occasional abdominal discomfort after oral administration
  • Nausea and vomiting

Pregnancy & Lactation

  • No evidence of teratogenicity or toxicity in human studies
  • Caution recommended for pregnant patients and lactating mothers
  • Erythromycin crosses the placental barrier and is excreted in breast milk

Precautions & Warnings

  • Should be given with care in patients with impaired hepatic function

Overdose Effects

  • Discontinue Erymex in case of overdosage
  • Prompt elimination of unabsorbed drug
  • Other appropriate measures should be instituted

Therapeutic Class

  • Anti-diarrhoeal Antimicrobial drugs
  • Macrolides

Reconstitution

  • Direction for reconstitution of suspension
  • Shake the bottle to loosen powder
  • Add boiled and cooled water to the dry powder
  • Shake well after each addition
  • Reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator
  • Unused portion should be discarded after 7 days

Storage Conditions

  • Keep below 25°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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